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Protein
Submitted name:

Isocitrate dehydrogenase Icd2

Gene

TBFG_10066

Organism
Mycobacterium tuberculosis (strain F11)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-69-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase Icd2Imported
Submitted name:
Isocitrate dehydrogenase [NADP] icd2Imported
Gene namesi
Ordered Locus Names:TBFG_10066Imported
ORF Names:P426_00069Imported
OrganismiMycobacterium tuberculosis (strain F11)Imported
Taxonomic identifieri336982 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000660: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi336982.TBFG_10066.

Structurei

3D structure databases

ProteinModelPortaliA5WIC0.
SMRiA5WIC0. Positions 6-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WIC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI
60 70 80 90 100
LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK
110 120 130 140 150
ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM
210 220 230 240 250
ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS
310 320 330 340 350
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT
460 470 480 490 500
ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE
510 520 530 540 550
LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN
610 620 630 640 650
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP
660 670 680 690 700
SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV
710 720 730 740
IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG
Length:745
Mass (Da):82,550
Last modified:July 28, 2009 - v1
Checksum:iA90FA68EDA105EF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR04409.1.
JLDC01000001 Genomic DNA. Translation: KBJ38806.1.
RefSeqiYP_001286011.1. NC_009565.1.

Genome annotation databases

EnsemblBacteriaiABR04409; ABR04409; TBFG_10066.
KBJ38806; KBJ38806; P426_00069.
GeneIDi5220729.
KEGGimtf:TBFG_10066.
PATRICi18130801. VBIMycTub9078_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR04409.1.
JLDC01000001 Genomic DNA. Translation: KBJ38806.1.
RefSeqiYP_001286011.1. NC_009565.1.

3D structure databases

ProteinModelPortaliA5WIC0.
SMRiA5WIC0. Positions 6-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336982.TBFG_10066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR04409; ABR04409; TBFG_10066.
KBJ38806; KBJ38806; P426_00069.
GeneIDi5220729.
KEGGimtf:TBFG_10066.
PATRICi18130801. VBIMycTub9078_0074.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-69-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F11Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.

Entry informationi

Entry nameiA5WIC0_MYCTF
AccessioniPrimary (citable) accession number: A5WIC0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.