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A5WIC0 (A5WIC0_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Isocitrate dehydrogenase [NADP] icd2 EMBL ABR04409.1
Gene names
Ordered Locus Names:TBFG_10066 EMBL ABR04409.1
ORF Names:P426_00069 EMBL KBJ38806.1
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP] EMBL ABR04409.1
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region134 – 1418Substrate binding By similarity PIRSR PIRSR009407-2

Sites

Metal binding3521Magnesium or manganese By similarity PIRSR PIRSR009407-3
Metal binding5511Magnesium or manganese By similarity PIRSR PIRSR009407-3
Metal binding5551Magnesium or manganese By similarity PIRSR PIRSR009407-3
Binding site1471Substrate By similarity PIRSR PIRSR009407-2
Binding site5501Substrate By similarity PIRSR PIRSR009407-2
Site2571Critical for catalysis By similarity PIRSR PIRSR009407-1
Site4221Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

Sequence LengthMass (Da)Tools
A5WIC0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: A90FA68EDA105EF3

FASTA74582,550
        10         20         30         40         50         60 
MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI LAEFPDYLTE 

        70         80         90        100        110        120 
EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK ELQDKGYAVP DYPADPKTDQ 

       130        140        150        160        170        180 
EKAIKERYAR CLGSAVNPVL RQGNSDRRAP KAVKEYARKH PHSMGEWSMA SRTHVAHMRH 

       190        200        210        220        230        240 
GDFYAGEKSM TLDRARNVRM ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE 

       250        260        270        280        290        300 
QMQDAFETGV MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 

       310        320        330        340        350        360 
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI VDASMPAMIR 

       370        380        390        400        410        420 
AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ FDPTTMGTVP NVGLMAQQAE 

       430        440        450        460        470        480 
EYGSHDKTFE IPEDGVANIV DVATGEVLLT ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA 

       490        500        510        520        530        540 
RISGMPVLFW LDPYRPHENE LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD 

       550        560        570        580        590        600 
TIAATGNILR DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 

       610        620        630        640        650        660 
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP SRKTGELDNR 

       670        680        690        700        710        720 
GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV IVRELTEVQG EPVDIGGYYA 

       730        740 
PDSDMTTAVM RPSKTFNAAL EAVQG 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of Mycobacterium tuberculosis F11."
Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. expand/collapse author list , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F11.
[2]"The Complete Genome Sequence of Mycobacterium tuberculosis F11."
The Broad Institute Genome Sequencing Platform
Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. expand/collapse author list , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F11 EMBL ABR04409.1.
[3]"The Genome Sequence of Mycobacterium tuberculosis F11."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C. expand/collapse author list , Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F11 EMBL KBJ38806.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000717 Genomic DNA. Translation: ABR04409.1.
JLDC01000001 Genomic DNA. Translation: KBJ38806.1.
RefSeqYP_001286011.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WIC0.
SMRA5WIC0. Positions 6-740.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336982.TBFG_10066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR04409; ABR04409; TBFG_10066.
GeneID5220729.
KEGGmtf:TBFG_10066.
PATRIC18130801. VBIMycTub9078_0074.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2838.
HOGENOMHOG000240860.
KOK00031.
OMAEEQRIGD.
OrthoDBEOG6DVJPP.

Enzyme and pathway databases

BioCycMTUB336982:GH7I-69-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 3 hits.
InterProIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamPF03971. IDH. 1 hit.
[Graphical view]
PIRSFPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsTIGR00178. monomer_idh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5WIC0_MYCTF
AccessionPrimary (citable) accession number: A5WIC0
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 9, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)