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A5WIC0

- A5WIC0_MYCTF

UniProt

A5WIC0 - A5WIC0_MYCTF

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Protein
Submitted name:

Isocitrate dehydrogenase Icd2

Gene
TBFG_10066, P426_00069
Organism
Mycobacterium tuberculosis (strain F11)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarity
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarity
Metal bindingi555 – 5551Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-69-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase Icd2Imported
Submitted name:
Isocitrate dehydrogenase [NADP] icd2Imported
Gene namesi
Ordered Locus Names:TBFG_10066Imported
ORF Names:P426_00069Imported
OrganismiMycobacterium tuberculosis (strain F11)Imported
Taxonomic identifieri336982 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000660: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi336982.TBFG_10066.

Structurei

3D structure databases

ProteinModelPortaliA5WIC0.
SMRiA5WIC0. Positions 6-740.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WIC0-1 [UniParc]FASTAAdd to Basket

« Hide

MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI    50
LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK 100
ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP 150
KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM 200
ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV 250
MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 300
DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI 350
VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ 400
FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT 450
ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE 500
LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR 550
DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP 650
SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV 700
IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG 745
Length:745
Mass (Da):82,550
Last modified:July 28, 2009 - v1
Checksum:iA90FA68EDA105EF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000717 Genomic DNA. Translation: ABR04409.1.
JLDC01000001 Genomic DNA. Translation: KBJ38806.1.
RefSeqiYP_001286011.1. NC_009565.1.

Genome annotation databases

EnsemblBacteriaiABR04409; ABR04409; TBFG_10066.
GeneIDi5220729.
KEGGimtf:TBFG_10066.
PATRICi18130801. VBIMycTub9078_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000717 Genomic DNA. Translation: ABR04409.1 .
JLDC01000001 Genomic DNA. Translation: KBJ38806.1 .
RefSeqi YP_001286011.1. NC_009565.1.

3D structure databases

ProteinModelPortali A5WIC0.
SMRi A5WIC0. Positions 6-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336982.TBFG_10066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR04409 ; ABR04409 ; TBFG_10066 .
GeneIDi 5220729.
KEGGi mtf:TBFG_10066.
PATRICi 18130801. VBIMycTub9078_0074.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci MTUB336982:GH7I-69-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F11.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.

Entry informationi

Entry nameiA5WIC0_MYCTF
AccessioniPrimary (citable) accession number: A5WIC0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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