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A5WIC0

- A5WIC0_MYCTF

UniProt

A5WIC0 - A5WIC0_MYCTF

Protein
Submitted name:

Isocitrate dehydrogenase Icd2

Gene

TBFG_10066

Organism
Mycobacterium tuberculosis (strain F11)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysis
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
    Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciMTUB336982:GH7I-69-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase Icd2Imported
    Submitted name:
    Isocitrate dehydrogenase [NADP] icd2Imported
    Gene namesi
    Ordered Locus Names:TBFG_10066Imported
    ORF Names:P426_00069Imported
    OrganismiMycobacterium tuberculosis (strain F11)Imported
    Taxonomic identifieri336982 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000000660: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi336982.TBFG_10066.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WIC0.
    SMRiA5WIC0. Positions 6-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5WIC0-1 [UniParc]FASTAAdd to Basket

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    MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI    50
    LAEFPDYLTE EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK 100
    ELQDKGYAVP DYPADPKTDQ EKAIKERYAR CLGSAVNPVL RQGNSDRRAP 150
    KAVKEYARKH PHSMGEWSMA SRTHVAHMRH GDFYAGEKSM TLDRARNVRM 200
    ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE QMQDAFETGV 250
    MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 300
    DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI 350
    VDASMPAMIR AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ 400
    FDPTTMGTVP NVGLMAQQAE EYGSHDKTFE IPEDGVANIV DVATGEVLLT 450
    ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA RISGMPVLFW LDPYRPHENE 500
    LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD TIAATGNILR 550
    DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 600
    HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP 650
    SRKTGELDNR GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV 700
    IVRELTEVQG EPVDIGGYYA PDSDMTTAVM RPSKTFNAAL EAVQG 745
    Length:745
    Mass (Da):82,550
    Last modified:July 28, 2009 - v1
    Checksum:iA90FA68EDA105EF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000717 Genomic DNA. Translation: ABR04409.1.
    JLDC01000001 Genomic DNA. Translation: KBJ38806.1.
    RefSeqiYP_001286011.1. NC_009565.1.

    Genome annotation databases

    EnsemblBacteriaiABR04409; ABR04409; TBFG_10066.
    GeneIDi5220729.
    KEGGimtf:TBFG_10066.
    PATRICi18130801. VBIMycTub9078_0074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000717 Genomic DNA. Translation: ABR04409.1 .
    JLDC01000001 Genomic DNA. Translation: KBJ38806.1 .
    RefSeqi YP_001286011.1. NC_009565.1.

    3D structure databases

    ProteinModelPortali A5WIC0.
    SMRi A5WIC0. Positions 6-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336982.TBFG_10066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR04409 ; ABR04409 ; TBFG_10066 .
    GeneIDi 5220729.
    KEGGi mtf:TBFG_10066.
    PATRICi 18130801. VBIMycTub9078_0074.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci MTUB336982:GH7I-69-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F11Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: F11Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: F11Imported.

    Entry informationi

    Entry nameiA5WIC0_MYCTF
    AccessioniPrimary (citable) accession number: A5WIC0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3