A5WIC0 (A5WIC0_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NADP] icd2 EMBL ABR04409.1

Gene names

Ordered Locus Names:

TBFG_10066

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP] EMBL ABR04409.1

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium tuberculosis

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	551	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	555	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	550	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	A5WIC0 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: A90FA68EDA105EF3	FASTA	745	82,550
	10 20 30 40 50 60 MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI LAEFPDYLTE 70 80 90 100 110 120 EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK ELQDKGYAVP DYPADPKTDQ 130 140 150 160 170 180 EKAIKERYAR CLGSAVNPVL RQGNSDRRAP KAVKEYARKH PHSMGEWSMA SRTHVAHMRH 190 200 210 220 230 240 GDFYAGEKSM TLDRARNVRM ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE 250 260 270 280 290 300 QMQDAFETGV MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS 310 320 330 340 350 360 DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI VDASMPAMIR 370 380 390 400 410 420 AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ FDPTTMGTVP NVGLMAQQAE 430 440 450 460 470 480 EYGSHDKTFE IPEDGVANIV DVATGEVLLT ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA 490 500 510 520 530 540 RISGMPVLFW LDPYRPHENE LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD 550 560 570 580 590 600 TIAATGNILR DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN 610 620 630 640 650 660 HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP SRKTGELDNR 670 680 690 700 710 720 GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV IVRELTEVQG EPVDIGGYYA 730 740 PDSDMTTAVM RPSKTFNAAL EAVQG

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: F11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR04409.1.
RefSeq	YP_001286011.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WIC0.
SMR	A5WIC0. Positions 6-740.
ModBase	Search...
Protein-protein interaction databases
STRING	336982.TBFG_10066.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR04409; ABR04409; TBFG_10066.
GeneID	5220729.
KEGG	mtf:TBFG_10066.
PATRIC	18130801. VBIMycTub9078_0074.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	PRTMGTV.
ProtClustDB	CLSK867411.
Enzyme and pathway databases
BioCyc	MTUB336982:GH7I-114-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WIC0_MYCTF

Accession

Primary (citable) accession number: A5WIC0

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)