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A5WI04

- FTHS_PSYWF

UniProt

A5WI04 - FTHS_PSYWF

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, PsycPRwf_2355
Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-2426-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:PsycPRwf_2355
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000073556Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_2355.

Structurei

3D structure databases

ProteinModelPortaliA5WI04.
SMRiA5WI04. Positions 6-567.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WI04-1 [UniParc]FASTAAdd to Basket

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MTVPSDITIA QNATLRPIVD IAKKIGLSAD KIEPYGYYKA KINPNDVFDM    50
PAKSSNSKLV LVTAINPTPA GEGKTTVTIG LADALNRVHH QDQNGKRTVV 100
ALREPSVGPV FGIKGGAAGG GYAQVLPMED INLHFTGDLH AIGAANNLLA 150
ALIDNHIYQG NALNIDPKQV VWRRAVDMND RQLRNTVTGL GKPADGVMRE 200
DGFDITVASE VMAIFCLATD LADLKQRLGN ILVAYNQDKQ PIYAKDLKAH 250
GAMAALLKDA IKPNLVQTIE GTPAILHGGP FANIAHGCNS VIATRTAMHL 300
ADYTLTEAGF GADLGAEKFC DIKCRLAGLT PDAAVVVATI RALKYNGGAA 350
KDALKNEDLT ALEQGLPNLT KHIENLQEVF GLPVVVAINQ FESDTAAEIE 400
MVRKACKRLK VEVALTQVWE KGGAGGEDLA RTLLALLETH NDQPQTFGFA 450
YDSNKPIVNK IRTVAQRIYG ANDVDISVTA AAKIKRLEAL GLDKMPICIA 500
KTQYSLSDDA KLLGRPTGFN IHVRDISVSN GAGFIVVICG PIMKMPGLPK 550
YPSAENIDVD EKGNITGLF 569
Length:569
Mass (Da):60,834
Last modified:July 10, 2007 - v1
Checksum:i2EC061E82362AE3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ95295.1.
RefSeqiWP_011961566.1. NC_009524.1.
YP_001281245.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ95295; ABQ95295; PsycPRwf_2355.
GeneIDi5205124.
KEGGiprw:PsycPRwf_2355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ95295.1 .
RefSeqi WP_011961566.1. NC_009524.1.
YP_001281245.1. NC_009524.1.

3D structure databases

ProteinModelPortali A5WI04.
SMRi A5WI04. Positions 6-567.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349106.PsycPRwf_2355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ95295 ; ABQ95295 ; PsycPRwf_2355 .
GeneIDi 5205124.
KEGGi prw:PsycPRwf_2355.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PPRW349106:GHZF-2426-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiFTHS_PSYWF
AccessioniPrimary (citable) accession number: A5WI04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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