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A5WI04 (FTHS_PSYWF) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PsycPRwf_2355
OrganismPsychrobacter sp. (strain PRwf-1) [Complete proteome] [HAMAP]
Taxonomic identifier349106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000073556

Regions

Nucleotide binding68 – 758ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5WI04 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 2EC061E82362AE3B

FASTA56960,834
        10         20         30         40         50         60 
MTVPSDITIA QNATLRPIVD IAKKIGLSAD KIEPYGYYKA KINPNDVFDM PAKSSNSKLV 

        70         80         90        100        110        120 
LVTAINPTPA GEGKTTVTIG LADALNRVHH QDQNGKRTVV ALREPSVGPV FGIKGGAAGG 

       130        140        150        160        170        180 
GYAQVLPMED INLHFTGDLH AIGAANNLLA ALIDNHIYQG NALNIDPKQV VWRRAVDMND 

       190        200        210        220        230        240 
RQLRNTVTGL GKPADGVMRE DGFDITVASE VMAIFCLATD LADLKQRLGN ILVAYNQDKQ 

       250        260        270        280        290        300 
PIYAKDLKAH GAMAALLKDA IKPNLVQTIE GTPAILHGGP FANIAHGCNS VIATRTAMHL 

       310        320        330        340        350        360 
ADYTLTEAGF GADLGAEKFC DIKCRLAGLT PDAAVVVATI RALKYNGGAA KDALKNEDLT 

       370        380        390        400        410        420 
ALEQGLPNLT KHIENLQEVF GLPVVVAINQ FESDTAAEIE MVRKACKRLK VEVALTQVWE 

       430        440        450        460        470        480 
KGGAGGEDLA RTLLALLETH NDQPQTFGFA YDSNKPIVNK IRTVAQRIYG ANDVDISVTA 

       490        500        510        520        530        540 
AAKIKRLEAL GLDKMPICIA KTQYSLSDDA KLLGRPTGFN IHVRDISVSN GAGFIVVICG 

       550        560 
PIMKMPGLPK YPSAENIDVD EKGNITGLF 

« Hide

References

[1]"Complete sequence of chromosome of Psychrobacter sp. PRwf-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PRwf-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000713 Genomic DNA. Translation: ABQ95295.1.
RefSeqYP_001281245.1. NC_009524.1.

3D structure databases

ProteinModelPortalA5WI04.
SMRA5WI04. Positions 6-567.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349106.PsycPRwf_2355.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ95295; ABQ95295; PsycPRwf_2355.
GeneID5205124.
KEGGprw:PsycPRwf_2355.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycPPRW349106:GHZF-2426-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PSYWF
AccessionPrimary (citable) accession number: A5WI04
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways