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A5WI04

- FTHS_PSYWF

UniProt

A5WI04 - FTHS_PSYWF

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRW349106:GHZF-2426-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:PsycPRwf_2355
    OrganismiPsychrobacter sp. (strain PRwf-1)
    Taxonomic identifieri349106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000001993: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Formate--tetrahydrofolate ligasePRO_1000073556Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349106.PsycPRwf_2355.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WI04.
    SMRiA5WI04. Positions 6-567.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5WI04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVPSDITIA QNATLRPIVD IAKKIGLSAD KIEPYGYYKA KINPNDVFDM    50
    PAKSSNSKLV LVTAINPTPA GEGKTTVTIG LADALNRVHH QDQNGKRTVV 100
    ALREPSVGPV FGIKGGAAGG GYAQVLPMED INLHFTGDLH AIGAANNLLA 150
    ALIDNHIYQG NALNIDPKQV VWRRAVDMND RQLRNTVTGL GKPADGVMRE 200
    DGFDITVASE VMAIFCLATD LADLKQRLGN ILVAYNQDKQ PIYAKDLKAH 250
    GAMAALLKDA IKPNLVQTIE GTPAILHGGP FANIAHGCNS VIATRTAMHL 300
    ADYTLTEAGF GADLGAEKFC DIKCRLAGLT PDAAVVVATI RALKYNGGAA 350
    KDALKNEDLT ALEQGLPNLT KHIENLQEVF GLPVVVAINQ FESDTAAEIE 400
    MVRKACKRLK VEVALTQVWE KGGAGGEDLA RTLLALLETH NDQPQTFGFA 450
    YDSNKPIVNK IRTVAQRIYG ANDVDISVTA AAKIKRLEAL GLDKMPICIA 500
    KTQYSLSDDA KLLGRPTGFN IHVRDISVSN GAGFIVVICG PIMKMPGLPK 550
    YPSAENIDVD EKGNITGLF 569
    Length:569
    Mass (Da):60,834
    Last modified:July 10, 2007 - v1
    Checksum:i2EC061E82362AE3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ95295.1.
    RefSeqiWP_011961566.1. NC_009524.1.
    YP_001281245.1. NC_009524.1.

    Genome annotation databases

    EnsemblBacteriaiABQ95295; ABQ95295; PsycPRwf_2355.
    GeneIDi5205124.
    KEGGiprw:PsycPRwf_2355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ95295.1 .
    RefSeqi WP_011961566.1. NC_009524.1.
    YP_001281245.1. NC_009524.1.

    3D structure databases

    ProteinModelPortali A5WI04.
    SMRi A5WI04. Positions 6-567.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349106.PsycPRwf_2355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ95295 ; ABQ95295 ; PsycPRwf_2355 .
    GeneIDi 5205124.
    KEGGi prw:PsycPRwf_2355.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PPRW349106:GHZF-2426-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PRwf-1.

    Entry informationi

    Entry nameiFTHS_PSYWF
    AccessioniPrimary (citable) accession number: A5WI04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3