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A5WGH9

- SYL_PSYWF

UniProt

A5WGH9 - SYL_PSYWF

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Protein

Leucine--tRNA ligase

Gene
leuS, PsycPRwf_1830
Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-1867-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PsycPRwf_1830
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligaseUniRule annotationPRO_0000334799Add
BLAST

Proteomic databases

PRIDEiA5WGH9.

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1830.

Structurei

3D structure databases

ProteinModelPortaliA5WGH9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionUniRule annotationAdd
BLAST
Motifi631 – 6355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WGH9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTTAPEQNN PNHYHPQAIE AEQQAKWAAD KRFEVSNDIS KDANTRYMLS    50
MFPYPSGKLH MGHVRNYTIS DVLSRYYRLK GDQVLQPMGW DAFGMPAENA 100
AIANQVAPAK WTFSNIDNMR AQLKTLGLSI DWSREFATCT PEYYRWEQWF 150
FLQLYKKGLV YKKLATVNWD PVDNTVLANE QVVDGKGWRS GAPVEKRDIP 200
MYYFKITDYA DELLDDLDKL EGQWPSDVIT MQRNWIGRSQ GMEVHFPYKN 250
SDDISTLDVF TTRPDTLMGV TYVAVAAEHR LAKLAAEKDP KIAEFCELCK 300
KGSVAEADLA KAEKIGMDTG LTVTHPLTGE EVPVWVANYV LMSYGSGAVM 350
AVPAHDERDF EFANKYNLPI KTVIKTPEDH EGAYTERGTL VNSGEFDGLD 400
FDGSFEAMLA KLEPQKLAAR KIQYRLRDWG VSRQRYWGCP IPMINCEYCG 450
NVPVDEADLP IKLPTDVVPD GRGNPLKNIP EFVNTTCPKC GGPAERETDT 500
FDTFMESSWY YARFASPNDD TQMVEKAAAD KWLPVDQYVG GVEHAVMHLL 550
YARFYHKLMR DEGLVSGDEP FKNLLTQGMV LAGTLYRDNP EGGKTYYFAD 600
DVEISYDDRG QPTQAILKAD GQPVTIGKIE KMSKSKNNGV DPQTTIDQYG 650
ADTVRLYTLF AAPADQTLEW SDDSLKGPYN FLKKVWRETQ SHLEATQELG 700
LQVANLPAAS SIDASQLDSL AKGLRRKTHE VITKIDNDLG ERLSLNTPVS 750
SLMELANEIG TFISKNQQIN EHTLAVQHEA LVTLLTLLSV YAPHIGEHLL 800
EKLGVDTTRL RYPEADSAAL VQDTITMVVQ VNGKVRGKME VAPGTDAESL 850
KAQAKAIESV AKYLTGDIKK EIVVPNKLVN IVVAG 885
Length:885
Mass (Da):99,051
Last modified:July 10, 2007 - v1
Checksum:i7CCF3ED1AB03D728
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ94770.1.
RefSeqiWP_011961047.1. NC_009524.1.
YP_001280720.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ94770; ABQ94770; PsycPRwf_1830.
GeneIDi5205852.
KEGGiprw:PsycPRwf_1830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ94770.1 .
RefSeqi WP_011961047.1. NC_009524.1.
YP_001280720.1. NC_009524.1.

3D structure databases

ProteinModelPortali A5WGH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349106.PsycPRwf_1830.

Proteomic databases

PRIDEi A5WGH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ94770 ; ABQ94770 ; PsycPRwf_1830 .
GeneIDi 5205852.
KEGGi prw:PsycPRwf_1830.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PPRW349106:GHZF-1867-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiSYL_PSYWF
AccessioniPrimary (citable) accession number: A5WGH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi