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A5WGH9

- SYL_PSYWF

UniProt

A5WGH9 - SYL_PSYWF

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei634 – 6341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRW349106:GHZF-1867-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PsycPRwf_1830
    OrganismiPsychrobacter sp. (strain PRwf-1)
    Taxonomic identifieri349106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000001993: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 885885Leucine--tRNA ligasePRO_0000334799Add
    BLAST

    Proteomic databases

    PRIDEiA5WGH9.

    Interactioni

    Protein-protein interaction databases

    STRINGi349106.PsycPRwf_1830.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WGH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi53 – 6311"HIGH" regionAdd
    BLAST
    Motifi631 – 6355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5WGH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTTAPEQNN PNHYHPQAIE AEQQAKWAAD KRFEVSNDIS KDANTRYMLS    50
    MFPYPSGKLH MGHVRNYTIS DVLSRYYRLK GDQVLQPMGW DAFGMPAENA 100
    AIANQVAPAK WTFSNIDNMR AQLKTLGLSI DWSREFATCT PEYYRWEQWF 150
    FLQLYKKGLV YKKLATVNWD PVDNTVLANE QVVDGKGWRS GAPVEKRDIP 200
    MYYFKITDYA DELLDDLDKL EGQWPSDVIT MQRNWIGRSQ GMEVHFPYKN 250
    SDDISTLDVF TTRPDTLMGV TYVAVAAEHR LAKLAAEKDP KIAEFCELCK 300
    KGSVAEADLA KAEKIGMDTG LTVTHPLTGE EVPVWVANYV LMSYGSGAVM 350
    AVPAHDERDF EFANKYNLPI KTVIKTPEDH EGAYTERGTL VNSGEFDGLD 400
    FDGSFEAMLA KLEPQKLAAR KIQYRLRDWG VSRQRYWGCP IPMINCEYCG 450
    NVPVDEADLP IKLPTDVVPD GRGNPLKNIP EFVNTTCPKC GGPAERETDT 500
    FDTFMESSWY YARFASPNDD TQMVEKAAAD KWLPVDQYVG GVEHAVMHLL 550
    YARFYHKLMR DEGLVSGDEP FKNLLTQGMV LAGTLYRDNP EGGKTYYFAD 600
    DVEISYDDRG QPTQAILKAD GQPVTIGKIE KMSKSKNNGV DPQTTIDQYG 650
    ADTVRLYTLF AAPADQTLEW SDDSLKGPYN FLKKVWRETQ SHLEATQELG 700
    LQVANLPAAS SIDASQLDSL AKGLRRKTHE VITKIDNDLG ERLSLNTPVS 750
    SLMELANEIG TFISKNQQIN EHTLAVQHEA LVTLLTLLSV YAPHIGEHLL 800
    EKLGVDTTRL RYPEADSAAL VQDTITMVVQ VNGKVRGKME VAPGTDAESL 850
    KAQAKAIESV AKYLTGDIKK EIVVPNKLVN IVVAG 885
    Length:885
    Mass (Da):99,051
    Last modified:July 10, 2007 - v1
    Checksum:i7CCF3ED1AB03D728
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ94770.1.
    RefSeqiWP_011961047.1. NC_009524.1.
    YP_001280720.1. NC_009524.1.

    Genome annotation databases

    EnsemblBacteriaiABQ94770; ABQ94770; PsycPRwf_1830.
    GeneIDi5205852.
    KEGGiprw:PsycPRwf_1830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ94770.1 .
    RefSeqi WP_011961047.1. NC_009524.1.
    YP_001280720.1. NC_009524.1.

    3D structure databases

    ProteinModelPortali A5WGH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349106.PsycPRwf_1830.

    Proteomic databases

    PRIDEi A5WGH9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ94770 ; ABQ94770 ; PsycPRwf_1830 .
    GeneIDi 5205852.
    KEGGi prw:PsycPRwf_1830.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PPRW349106:GHZF-1867-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PRwf-1.

    Entry informationi

    Entry nameiSYL_PSYWF
    AccessioniPrimary (citable) accession number: A5WGH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3