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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-1867-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PsycPRwf_1830
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligasePRO_0000334799Add
BLAST

Proteomic databases

PRIDEiA5WGH9.

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1830.

Structurei

3D structure databases

ProteinModelPortaliA5WGH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionAdd
BLAST
Motifi631 – 6355"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WGH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTAPEQNN PNHYHPQAIE AEQQAKWAAD KRFEVSNDIS KDANTRYMLS
60 70 80 90 100
MFPYPSGKLH MGHVRNYTIS DVLSRYYRLK GDQVLQPMGW DAFGMPAENA
110 120 130 140 150
AIANQVAPAK WTFSNIDNMR AQLKTLGLSI DWSREFATCT PEYYRWEQWF
160 170 180 190 200
FLQLYKKGLV YKKLATVNWD PVDNTVLANE QVVDGKGWRS GAPVEKRDIP
210 220 230 240 250
MYYFKITDYA DELLDDLDKL EGQWPSDVIT MQRNWIGRSQ GMEVHFPYKN
260 270 280 290 300
SDDISTLDVF TTRPDTLMGV TYVAVAAEHR LAKLAAEKDP KIAEFCELCK
310 320 330 340 350
KGSVAEADLA KAEKIGMDTG LTVTHPLTGE EVPVWVANYV LMSYGSGAVM
360 370 380 390 400
AVPAHDERDF EFANKYNLPI KTVIKTPEDH EGAYTERGTL VNSGEFDGLD
410 420 430 440 450
FDGSFEAMLA KLEPQKLAAR KIQYRLRDWG VSRQRYWGCP IPMINCEYCG
460 470 480 490 500
NVPVDEADLP IKLPTDVVPD GRGNPLKNIP EFVNTTCPKC GGPAERETDT
510 520 530 540 550
FDTFMESSWY YARFASPNDD TQMVEKAAAD KWLPVDQYVG GVEHAVMHLL
560 570 580 590 600
YARFYHKLMR DEGLVSGDEP FKNLLTQGMV LAGTLYRDNP EGGKTYYFAD
610 620 630 640 650
DVEISYDDRG QPTQAILKAD GQPVTIGKIE KMSKSKNNGV DPQTTIDQYG
660 670 680 690 700
ADTVRLYTLF AAPADQTLEW SDDSLKGPYN FLKKVWRETQ SHLEATQELG
710 720 730 740 750
LQVANLPAAS SIDASQLDSL AKGLRRKTHE VITKIDNDLG ERLSLNTPVS
760 770 780 790 800
SLMELANEIG TFISKNQQIN EHTLAVQHEA LVTLLTLLSV YAPHIGEHLL
810 820 830 840 850
EKLGVDTTRL RYPEADSAAL VQDTITMVVQ VNGKVRGKME VAPGTDAESL
860 870 880
KAQAKAIESV AKYLTGDIKK EIVVPNKLVN IVVAG
Length:885
Mass (Da):99,051
Last modified:July 10, 2007 - v1
Checksum:i7CCF3ED1AB03D728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ94770.1.
RefSeqiWP_011961047.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ94770; ABQ94770; PsycPRwf_1830.
KEGGiprw:PsycPRwf_1830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ94770.1.
RefSeqiWP_011961047.1. NC_009524.1.

3D structure databases

ProteinModelPortaliA5WGH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1830.

Proteomic databases

PRIDEiA5WGH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ94770; ABQ94770; PsycPRwf_1830.
KEGGiprw:PsycPRwf_1830.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-1867-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiSYL_PSYWF
AccessioniPrimary (citable) accession number: A5WGH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.