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A5WG08

- ASSY_PSYWF

UniProt

A5WG08 - ASSY_PSYWF

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei98 – 981CitrullineUniRule annotation
Binding sitei123 – 1231ATP; via amide nitrogenUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei129 – 1291AspartateUniRule annotation
Binding sitei129 – 1291CitrullineUniRule annotation
Binding sitei130 – 1301AspartateUniRule annotation
Binding sitei133 – 1331CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei194 – 1941CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation
Binding sitei282 – 2821CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-1690-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:PsycPRwf_1659
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Argininosuccinate synthasePRO_1000070915Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1659.

Structurei

3D structure databases

ProteinModelPortaliA5WG08.
SMRiA5WG08. Positions 11-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WG08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIENKDNIN KIVLAYSGGL DTSIIAKWLQ DTYDAEVITF TADIGQGEEV
60 70 80 90 100
EPARAKAEAM GIKHIHIEDL RAEFARDYVF PMFRANAIYE GEYLLGTSIA
110 120 130 140 150
RPLIAKRLVE IAKEHNADAI SHGATGKGND QVRFELGAIA LAPDVKTIAP
160 170 180 190 200
WREWDLSSRE SLMAYAKEHN IPIDFAANKK KSPYSMDANL LHISYEGDIL
210 220 230 240 250
EDPYAEAEDD MWRWSVSPEQ APDTPEYLEL EYEKGDIVAI NGEKLEPYEV
260 270 280 290 300
MIKLNELGGK HGIGRLDIVE NRYVGMKSRG CYETPAGTIM LKAHRGMESL
310 320 330 340 350
TLDREAAHLK DELMPRYAKI IYNGYWFSPE RQMLQALIDK SQEYVTGTVR
360 370 380 390 400
VKLYKGNVSV VGRKSPYSLF DEKIATFEDD AGAYDQKDAE GFIRLNGLRL
410
SIEASRGRDL S
Length:411
Mass (Da):46,272
Last modified:July 10, 2007 - v1
Checksum:iB71C5B6CD5AF8A35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ94599.1.
RefSeqiWP_011960877.1. NC_009524.1.
YP_001280549.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ94599; ABQ94599; PsycPRwf_1659.
GeneIDi5205349.
KEGGiprw:PsycPRwf_1659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000713 Genomic DNA. Translation: ABQ94599.1 .
RefSeqi WP_011960877.1. NC_009524.1.
YP_001280549.1. NC_009524.1.

3D structure databases

ProteinModelPortali A5WG08.
SMRi A5WG08. Positions 11-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349106.PsycPRwf_1659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ94599 ; ABQ94599 ; PsycPRwf_1659 .
GeneIDi 5205349.
KEGGi prw:PsycPRwf_1659.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci PPRW349106:GHZF-1690-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiASSY_PSYWF
AccessioniPrimary (citable) accession number: A5WG08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3