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A5WG08

- ASSY_PSYWF

UniProt

A5WG08 - ASSY_PSYWF

Protein

Argininosuccinate synthase

Gene

argG

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei93 – 931CitrullineUniRule annotation
    Binding sitei98 – 981CitrullineUniRule annotation
    Binding sitei123 – 1231ATP; via amide nitrogenUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei129 – 1291AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei130 – 1301AspartateUniRule annotation
    Binding sitei133 – 1331CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei194 – 1941CitrullineUniRule annotation
    Binding sitei270 – 2701CitrullineUniRule annotation
    Binding sitei282 – 2821CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRW349106:GHZF-1690-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:PsycPRwf_1659
    OrganismiPsychrobacter sp. (strain PRwf-1)
    Taxonomic identifieri349106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000001993: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Argininosuccinate synthasePRO_1000070915Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349106.PsycPRwf_1659.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WG08.
    SMRiA5WG08. Positions 11-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5WG08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIENKDNIN KIVLAYSGGL DTSIIAKWLQ DTYDAEVITF TADIGQGEEV    50
    EPARAKAEAM GIKHIHIEDL RAEFARDYVF PMFRANAIYE GEYLLGTSIA 100
    RPLIAKRLVE IAKEHNADAI SHGATGKGND QVRFELGAIA LAPDVKTIAP 150
    WREWDLSSRE SLMAYAKEHN IPIDFAANKK KSPYSMDANL LHISYEGDIL 200
    EDPYAEAEDD MWRWSVSPEQ APDTPEYLEL EYEKGDIVAI NGEKLEPYEV 250
    MIKLNELGGK HGIGRLDIVE NRYVGMKSRG CYETPAGTIM LKAHRGMESL 300
    TLDREAAHLK DELMPRYAKI IYNGYWFSPE RQMLQALIDK SQEYVTGTVR 350
    VKLYKGNVSV VGRKSPYSLF DEKIATFEDD AGAYDQKDAE GFIRLNGLRL 400
    SIEASRGRDL S 411
    Length:411
    Mass (Da):46,272
    Last modified:July 10, 2007 - v1
    Checksum:iB71C5B6CD5AF8A35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ94599.1.
    RefSeqiWP_011960877.1. NC_009524.1.
    YP_001280549.1. NC_009524.1.

    Genome annotation databases

    EnsemblBacteriaiABQ94599; ABQ94599; PsycPRwf_1659.
    GeneIDi5205349.
    KEGGiprw:PsycPRwf_1659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ94599.1 .
    RefSeqi WP_011960877.1. NC_009524.1.
    YP_001280549.1. NC_009524.1.

    3D structure databases

    ProteinModelPortali A5WG08.
    SMRi A5WG08. Positions 11-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349106.PsycPRwf_1659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ94599 ; ABQ94599 ; PsycPRwf_1659 .
    GeneIDi 5205349.
    KEGGi prw:PsycPRwf_1659.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci PPRW349106:GHZF-1690-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PRwf-1.

    Entry informationi

    Entry nameiASSY_PSYWF
    AccessioniPrimary (citable) accession number: A5WG08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3