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A5WFX4

- PUR9_PSYWF

UniProt

A5WFX4 - PUR9_PSYWF

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-1653-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:PsycPRwf_1624
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHPRO_1000071451Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1624.

Structurei

3D structure databases

ProteinModelPortaliA5WFX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WFX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDKPYALIS VSDKSQIESF AKGLIEAGYD LLSTGGTYRL LSDNGIAVTE
60 70 80 90 100
VADYTGFAEM MDGRVKTLHP KIHGGILGRR GQDDAVMSEH GIRPIDLVVV
110 120 130 140 150
NLYPFAQTVA KPDVTKADAI ENIDIGGPTM VRSAAKNHEH VAIVTNPADY
160 170 180 190 200
DVVLQELKDT GSISQKTRFD LAVKAFEHTA HYDGMIANFL GSRLESFEAP
210 220 230 240 250
DSFARTFNVQ LQKAQDLRYG ENPHQKAAFY VEANGSGEGS ISTAQQHQGK
260 270 280 290 300
ELSYNNIADT DAALECVKSF SESACVIVKH ANPCGVAINA DQTQAYKTAF
310 320 330 340 350
STDPESSFGG IIAFNRPLTK QTAQAIVDTQ FAEVIIAPSL EQGVLDITAA
360 370 380 390 400
KKNVRVLTCG ELPSPDQRAA QFDYKRVTGG LLIQNQDLGL ITADDLQVVT
410 420 430 440 450
DLKPTAEQLN DLLFTWTVAK YVKSNAIVYG KDQRTIGIGA GQMSRVNSAR
460 470 480 490 500
IAAIKAEHAN LATQGAVMAS DAFFPFRDGI DNAAEVGIKA IIQPGGSIRD
510 520
DETIAAANEH GIAMVFTGMR HFRH
Length:524
Mass (Da):56,499
Last modified:July 10, 2007 - v1
Checksum:i8D4D64C82902795A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ94565.1.
RefSeqiWP_011960845.1. NC_009524.1.
YP_001280515.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ94565; ABQ94565; PsycPRwf_1624.
GeneIDi5205092.
KEGGiprw:PsycPRwf_1624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ94565.1 .
RefSeqi WP_011960845.1. NC_009524.1.
YP_001280515.1. NC_009524.1.

3D structure databases

ProteinModelPortali A5WFX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349106.PsycPRwf_1624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ94565 ; ABQ94565 ; PsycPRwf_1624 .
GeneIDi 5205092.
KEGGi prw:PsycPRwf_1624.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PPRW349106:GHZF-1653-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiPUR9_PSYWF
AccessioniPrimary (citable) accession number: A5WFX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3