A5WC53 (MSRA_PSYWF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	PsycPRwf_0289

Organism

Psychrobacter sp. (strain PRwf-1) [Complete proteome] [HAMAP]

Taxonomic identifier

349106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000073501
Sites
	Active site	10	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5WC53 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 4ACC09E13A942951	FASTA	175	19,846
	10 20 30 40 50 60 MQTIILGGGC FWCTESVFQS VKGVQKVTSG YMGGEDANLA NYKDVCSGTT GHIEVVRVDF 70 80 90 100 110 120 DDTIVPLEVV LDIFFATHDP TTRDRQGNDI GSQYRSVVFY TDEETQKPTI DRTINKLRDM 130 140 150 160 170 GLDIVTEVHP VHEFHVAEDY HQDYFNKNPT QGYCQAVIPP KLGKLRKEFK QYMAK

References

[1]

"Complete sequence of chromosome of Psychrobacter sp. PRwf-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PRwf-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000713 Genomic DNA. Translation: ABQ93244.1.
RefSeq	YP_001279194.1. NC_009524.1.
3D structure databases
ProteinModelPortal	A5WC53.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WC53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5206012.
GenomeReviews	Gene locus PsycPRwf_0289 in contig CP000713_GR.
KEGG	prw:PsycPRwf_0289.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	IDTEVGY.
ProtClustDB	CLSK839537.
Enzyme and pathway databases
BioCyc	PSP56811:PSYCPRWF_0289-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_PSYWF

Accession

Primary (citable) accession number: A5WC53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program