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A5WBU9

- CPDA_PSYWF

UniProt

A5WBU9 - CPDA_PSYWF

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, PsycPRwf_0181
Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Metal cation 1 By similarity
Metal bindingi49 – 491Metal cation 1 By similarity
Binding sitei49 – 491cAMP By similarity
Metal bindingi128 – 1281Metal cation 1 By similarity
Metal bindingi128 – 1281Metal cation 2 By similarity
Binding sitei128 – 1281cAMP By similarity
Metal bindingi158 – 1581Metal cation 2 By similarity
Metal bindingi237 – 2371Metal cation 2 By similarity
Metal bindingi276 – 2761Metal cation 2 By similarity
Metal bindingi278 – 2781Metal cation 1 By similarity
Binding sitei278 – 2781cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1592cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRW349106:GHZF-185-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
    Short name:
    3',5'-cyclic AMP phosphodiesterase
    Short name:
    cAMP phosphodiesterase
    Gene namesi
    Name:cpdA
    Ordered Locus Names:PsycPRwf_0181
    OrganismiPsychrobacter sp. (strain PRwf-1)
    Taxonomic identifieri349106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000001993: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3403403',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
    PRO_0000413375Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349106.PsycPRwf_0181.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WBU9.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000289889.
    KOiK03651.
    OMAiLAGNHDN.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A5WBU9-1 [UniParc]FASTAAdd to Basket

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    MAPLPHSVSP RHTQVADNGR LSEPTDYHPP TEISTDDGTV NILQLTDLHL    50
    YFDTPKATHE QDINKDSAHQ TITGICQNNS AKRGNPHSAD AINHSVTPVI 100
    HNYASFEACL TQALSEDVRC DLIVVTGDLV SEIHPQLYQH LYQRLHQSGI 150
    PFACIAGNHD VTDEIGKDLP FEQRSFEPHE PDSRLLSRYS MKLNGWEILF 200
    INSSVPGQIF GRIGNKNLYW LSQKLANSHH PVIIAMHHHL LPMHSAWIDA 250
    HITQDATEFW QTVAPFNALK AVVGGHVHQS STRSYQGVQL YSTPSTGYQF 300
    KPGCDDFTLD DEAKPGYRWL SLKANGTLQS WVVRLEDNAG 340
    Length:340
    Mass (Da):38,004
    Last modified:July 10, 2007 - v1
    Checksum:iAAA4597C1CD1F684
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ93140.1.
    RefSeqiWP_011959475.1. NC_009524.1.
    YP_001279090.1. NC_009524.1.

    Genome annotation databases

    EnsemblBacteriaiABQ93140; ABQ93140; PsycPRwf_0181.
    GeneIDi5205964.
    KEGGiprw:PsycPRwf_0181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ93140.1 .
    RefSeqi WP_011959475.1. NC_009524.1.
    YP_001279090.1. NC_009524.1.

    3D structure databases

    ProteinModelPortali A5WBU9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 349106.PsycPRwf_0181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ93140 ; ABQ93140 ; PsycPRwf_0181 .
    GeneIDi 5205964.
    KEGGi prw:PsycPRwf_0181.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000289889.
    KOi K03651.
    OMAi LAGNHDN.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci PPRW349106:GHZF-185-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PRwf-1.

    Entry informationi

    Entry nameiCPDA_PSYWF
    AccessioniPrimary (citable) accession number: A5WBU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 10, 2007
    Last modified: September 3, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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