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A5WBU9

- CPDA_PSYWF

UniProt

A5WBU9 - CPDA_PSYWF

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Metal cation 1UniRule annotation
    Metal bindingi49 – 491Metal cation 1UniRule annotation
    Binding sitei49 – 491cAMPUniRule annotation
    Metal bindingi128 – 1281Metal cation 1UniRule annotation
    Metal bindingi128 – 1281Metal cation 2UniRule annotation
    Binding sitei128 – 1281cAMPUniRule annotation
    Metal bindingi158 – 1581Metal cation 2UniRule annotation
    Metal bindingi237 – 2371Metal cation 2UniRule annotation
    Metal bindingi276 – 2761Metal cation 2UniRule annotation
    Metal bindingi278 – 2781Metal cation 1UniRule annotation
    Binding sitei278 – 2781cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi158 – 1592cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPRW349106:GHZF-185-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:PsycPRwf_0181
    OrganismiPsychrobacter sp. (strain PRwf-1)
    Taxonomic identifieri349106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000001993: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3403403',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413375Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349106.PsycPRwf_0181.

    Structurei

    3D structure databases

    ProteinModelPortaliA5WBU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000289889.
    KOiK03651.
    OMAiLAGNHDN.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A5WBU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLPHSVSP RHTQVADNGR LSEPTDYHPP TEISTDDGTV NILQLTDLHL    50
    YFDTPKATHE QDINKDSAHQ TITGICQNNS AKRGNPHSAD AINHSVTPVI 100
    HNYASFEACL TQALSEDVRC DLIVVTGDLV SEIHPQLYQH LYQRLHQSGI 150
    PFACIAGNHD VTDEIGKDLP FEQRSFEPHE PDSRLLSRYS MKLNGWEILF 200
    INSSVPGQIF GRIGNKNLYW LSQKLANSHH PVIIAMHHHL LPMHSAWIDA 250
    HITQDATEFW QTVAPFNALK AVVGGHVHQS STRSYQGVQL YSTPSTGYQF 300
    KPGCDDFTLD DEAKPGYRWL SLKANGTLQS WVVRLEDNAG 340
    Length:340
    Mass (Da):38,004
    Last modified:July 10, 2007 - v1
    Checksum:iAAA4597C1CD1F684
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ93140.1.
    RefSeqiWP_011959475.1. NC_009524.1.
    YP_001279090.1. NC_009524.1.

    Genome annotation databases

    EnsemblBacteriaiABQ93140; ABQ93140; PsycPRwf_0181.
    GeneIDi5205964.
    KEGGiprw:PsycPRwf_0181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000713 Genomic DNA. Translation: ABQ93140.1 .
    RefSeqi WP_011959475.1. NC_009524.1.
    YP_001279090.1. NC_009524.1.

    3D structure databases

    ProteinModelPortali A5WBU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349106.PsycPRwf_0181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ93140 ; ABQ93140 ; PsycPRwf_0181 .
    GeneIDi 5205964.
    KEGGi prw:PsycPRwf_0181.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000289889.
    KOi K03651.
    OMAi LAGNHDN.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci PPRW349106:GHZF-185-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PRwf-1.

    Entry informationi

    Entry nameiCPDA_PSYWF
    AccessioniPrimary (citable) accession number: A5WBU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3