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A5WBU9

- CPDA_PSYWF

UniProt

A5WBU9 - CPDA_PSYWF

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Metal cation 1UniRule annotation
Metal bindingi49 – 491Metal cation 1UniRule annotation
Binding sitei49 – 491cAMPUniRule annotation
Metal bindingi128 – 1281Metal cation 1UniRule annotation
Metal bindingi128 – 1281Metal cation 2UniRule annotation
Binding sitei128 – 1281cAMPUniRule annotation
Metal bindingi158 – 1581Metal cation 2UniRule annotation
Metal bindingi237 – 2371Metal cation 2UniRule annotation
Metal bindingi276 – 2761Metal cation 2UniRule annotation
Metal bindingi278 – 2781Metal cation 1UniRule annotation
Binding sitei278 – 2781cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1592cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPRW349106:GHZF-185-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:PsycPRwf_0181
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000001993: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3403403',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413375Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_0181.

Structurei

3D structure databases

ProteinModelPortaliA5WBU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000289889.
KOiK03651.
OMAiLAGNHDN.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 2 hits.

Sequencei

Sequence statusi: Complete.

A5WBU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLPHSVSP RHTQVADNGR LSEPTDYHPP TEISTDDGTV NILQLTDLHL
60 70 80 90 100
YFDTPKATHE QDINKDSAHQ TITGICQNNS AKRGNPHSAD AINHSVTPVI
110 120 130 140 150
HNYASFEACL TQALSEDVRC DLIVVTGDLV SEIHPQLYQH LYQRLHQSGI
160 170 180 190 200
PFACIAGNHD VTDEIGKDLP FEQRSFEPHE PDSRLLSRYS MKLNGWEILF
210 220 230 240 250
INSSVPGQIF GRIGNKNLYW LSQKLANSHH PVIIAMHHHL LPMHSAWIDA
260 270 280 290 300
HITQDATEFW QTVAPFNALK AVVGGHVHQS STRSYQGVQL YSTPSTGYQF
310 320 330 340
KPGCDDFTLD DEAKPGYRWL SLKANGTLQS WVVRLEDNAG
Length:340
Mass (Da):38,004
Last modified:July 10, 2007 - v1
Checksum:iAAA4597C1CD1F684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ93140.1.
RefSeqiWP_011959475.1. NC_009524.1.
YP_001279090.1. NC_009524.1.

Genome annotation databases

EnsemblBacteriaiABQ93140; ABQ93140; PsycPRwf_0181.
GeneIDi5205964.
KEGGiprw:PsycPRwf_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA. Translation: ABQ93140.1 .
RefSeqi WP_011959475.1. NC_009524.1.
YP_001279090.1. NC_009524.1.

3D structure databases

ProteinModelPortali A5WBU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349106.PsycPRwf_0181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ93140 ; ABQ93140 ; PsycPRwf_0181 .
GeneIDi 5205964.
KEGGi prw:PsycPRwf_0181.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000289889.
KOi K03651.
OMAi LAGNHDN.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci PPRW349106:GHZF-185-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRwf-1.

Entry informationi

Entry nameiCPDA_PSYWF
AccessioniPrimary (citable) accession number: A5WBU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3