Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A5WBU9 (CPDA_PSYWF) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:PsycPRwf_0181
OrganismPsychrobacter sp. (strain PRwf-1) [Complete proteome] [HAMAP]
Taxonomic identifier349106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3403403',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413375

Regions

Nucleotide binding158 – 1592cAMP By similarity

Sites

Metal binding471Metal cation 1 By similarity
Metal binding491Metal cation 1 By similarity
Metal binding1281Metal cation 1 By similarity
Metal binding1281Metal cation 2 By similarity
Metal binding1581Metal cation 2 By similarity
Metal binding2371Metal cation 2 By similarity
Metal binding2761Metal cation 2 By similarity
Metal binding2781Metal cation 1 By similarity
Binding site491cAMP By similarity
Binding site1281cAMP By similarity
Binding site2781cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5WBU9 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: AAA4597C1CD1F684

FASTA34038,004
        10         20         30         40         50         60 
MAPLPHSVSP RHTQVADNGR LSEPTDYHPP TEISTDDGTV NILQLTDLHL YFDTPKATHE 

        70         80         90        100        110        120 
QDINKDSAHQ TITGICQNNS AKRGNPHSAD AINHSVTPVI HNYASFEACL TQALSEDVRC 

       130        140        150        160        170        180 
DLIVVTGDLV SEIHPQLYQH LYQRLHQSGI PFACIAGNHD VTDEIGKDLP FEQRSFEPHE 

       190        200        210        220        230        240 
PDSRLLSRYS MKLNGWEILF INSSVPGQIF GRIGNKNLYW LSQKLANSHH PVIIAMHHHL 

       250        260        270        280        290        300 
LPMHSAWIDA HITQDATEFW QTVAPFNALK AVVGGHVHQS STRSYQGVQL YSTPSTGYQF 

       310        320        330        340 
KPGCDDFTLD DEAKPGYRWL SLKANGTLQS WVVRLEDNAG 

« Hide

References

[1]"Complete sequence of chromosome of Psychrobacter sp. PRwf-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PRwf-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000713 Genomic DNA. Translation: ABQ93140.1.
RefSeqYP_001279090.1. NC_009524.1.

3D structure databases

ProteinModelPortalA5WBU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349106.PsycPRwf_0181.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ93140; ABQ93140; PsycPRwf_0181.
GeneID5205964.
KEGGprw:PsycPRwf_0181.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000289889.
KOK03651.
OMAWIDAHIT.
OrthoDBEOG6QG8GQ.
ProtClustDBCLSK839571.

Enzyme and pathway databases

BioCycPPRW349106:GHZF-185-MONOMER.

Family and domain databases

HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR013622. Calcineurin-like_phos_C.
IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
[Graphical view]
PfamPF12850. Metallophos_2. 1 hit.
[Graphical view]
ProDomPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameCPDA_PSYWF
AccessionPrimary (citable) accession number: A5WBU9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families