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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PsycPRwf_0131
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000001993 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309911 – 505Glutamate--tRNA ligaseAdd BLAST505

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349106.PsycPRwf_0131

Structurei

3D structure databases

ProteinModelPortaliA5WBQ0
SMRiA5WBQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi16 – 26"HIGH" regionUniRule annotationAdd BLAST11
Motifi257 – 261"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A5WBQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTTAQRPV RTRIAPSPTG FPHVGTAYIA LFNLAFAKAH GGEFILRIED
60 70 80 90 100
TDQSRSTEQS EQMILDALRW VGLDWAEGPD NGGPHAPYRQ SERSEIYKQY
110 120 130 140 150
AQELLDKGHA FRCFCTPEEL DAMRAEQIAR GENPHYDGRY ANLPREESDK
160 170 180 190 200
MAAEGKPFVI RMKVPTEGVC KVQDMLRGEV EIPWEQVDMQ VLLKTDGLPT
210 220 230 240 250
YHLANVVDDH LMEITHVIRG EEWLNSAPKH QLLYDYFGWE MPVLCHMPLL
260 270 280 290 300
RNPDKSKLSK RKNPTSITYY RDAGVLPEAL LNYLGRMGYS MPDDKEIFTL
310 320 330 340 350
DEMIESFDIT RVSLGGPIFD LEKLHWLNGE WLRALTPEQL KNKILDWAND
360 370 380 390 400
SDKLTAIAAA IQPRIHLLSD AVNWGGFYFQ NLPSITAESF EHKTLTPEQI
410 420 430 440 450
MEILQIATWK LEALPEWSED NIFKTLKGLS AALDIKLRDM MAPFFIAIAG
460 470 480 490 500
STSSTPVMNS MYVIGADMTL TRLRHAVEVL GGIGKKKLKK LEKTAADMPD

FLAAE
Length:505
Mass (Da):57,225
Last modified:July 10, 2007 - v1
Checksum:i28326DE12067A3D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA Translation: ABQ93091.1
RefSeqiWP_011959427.1, NC_009524.1

Genome annotation databases

EnsemblBacteriaiABQ93091; ABQ93091; PsycPRwf_0131
KEGGiprw:PsycPRwf_0131

Similar proteinsi

Entry informationi

Entry nameiSYE_PSYWF
AccessioniPrimary (citable) accession number: A5WBQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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