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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223UniRule annotation1
Active sitei225UniRule annotation1
Active sitei230UniRule annotation1
Active sitei397UniRule annotation1
Active sitei399UniRule annotation1
Active sitei404UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPPUT351746:G1G90-5490-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:Pput_5272
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001185931 – 479Cardiolipin synthase AAdd BLAST479

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_5272

Structurei

3D structure databases

ProteinModelPortaliA5WB80
SMRiA5WB80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 245PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini392 – 419PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077402
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

A5WB80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYHSPYFFG YLLGMIHLLG IVAALHALFT VRTAQGAIAW AMPLLFIPYL
60 70 80 90 100
TLIPYLIFGA RSFYAYIKAR RQANQEMHVA MANLNWRPWV EEALTARESE
110 120 130 140 150
SYAALRAMPK LGRMPCLANN QVKLLINGKA TFDAIFAAIE KARDVVLVQF
160 170 180 190 200
FIIHDDTLGK ALQQLLLRKA AEGVQVFVLY DRVGSHALPA SYSQMLRDGG
210 220 230 240 250
VQIHAFATRR GWFNRFQVNF RNHRKIVVVD GLLGFIGGHN VGDEYLGEHP
260 270 280 290 300
QLSPWRDTHV QISGPVLACL QESFAEDWYW ATRQLPPLIL PDTYPDNGVL
310 320 330 340 350
CQALASGPAD PQETCSLFFL EAIHSATRRV WITSPYFIPD EAVFAALRLA
360 370 380 390 400
VLRGVDVRVL IPSRPDHRIV YAASSLFAFE AVRAGVRMFR YQPGFLHQKV
410 420 430 440 450
VLVDDDVSAI GSANLDNRSF RLNFEITLLT VDRGFADQVE HMLHEDFEHA
460 470
REITAEDTQD THRLQQLGMR IARLISPIL
Length:479
Mass (Da):54,127
Last modified:July 10, 2007 - v1
Checksum:iEF4BF827B777685B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA Translation: ABQ81390.1
RefSeqiWP_012054132.1, NC_009512.1

Genome annotation databases

EnsemblBacteriaiABQ81390; ABQ81390; Pput_5272
KEGGippf:Pput_5272

Similar proteinsi

Entry informationi

Entry nameiCLSA_PSEP1
AccessioniPrimary (citable) accession number: A5WB80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health