Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Cofactori

FAD

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei475Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 35FADAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Pput_4937
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000465701 – 565Oxygen-dependent choline dehydrogenaseAdd BLAST565

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_4937.

Structurei

3D structure databases

ProteinModelPortaliA5WA97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.

Phylogenomic databases

eggNOGiENOG4105CZ6. Bacteria.
COG2303. LUCA.
HOGENOMiHOG000139600.
KOiK00108.
OMAiGWDYAHC.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiView protein in InterPro
IPR011533. BetA.
IPR036188. FAD/NAD-bd_sf.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
PANTHERiPTHR11552:SF157. PTHR11552:SF157. 1 hit.
PfamiView protein in Pfam
PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiView protein in PROSITE
PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WA97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEFDYIIV GAGSAGNTLA TRLTEDAGVT VLLLEAGGPD YRFDFRTQMP
60 70 80 90 100
AALAFPLQGR RYNWAYETDP EPYMDGRRME CGRGKGLGGS SLINGMCYIR
110 120 130 140 150
GNAMDFDGWA ELPGLEDWTY LDCLPYFRKA ETRDIGPNDY HGGDGPVSVA
160 170 180 190 200
TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG YQQEGFGPMD RSVTKNGRRS
210 220 230 240 250
STARGYLDQA KKRPNLTIVT HALTDRVLFD GKRAVGVTYL VGDSEERVEA
260 270 280 290 300
RARKEVIVSS GAIASPQLLQ RSGVGPRALL ESLDIPVVHD LPGVGENLQD
310 320 330 340 350
HLELYLQYAC TQPVSLYPSL LWWNQPAIGA EWLFNGTGIG ASNQFEAGGF
360 370 380 390 400
IRTRPEFKWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPARGRIQ
410 420 430 440 450
AKSKDPRQHP SILFNYMSTE QDWQEFRDGI RLTREIMAQP ALDPYRGREI
460 470 480 490 500
SPGAHVQTDE ELDKFIREHA ETAFHPSCSC KMGTDDMAVV DGEGRVHGMK
510 520 530 540 550
GLRVVDASIM PLIITGNLNA TTIMIAEKIS DKIRGRKPLP RSTAKYYVAG
560
DAPVKGKPMR EVKQG
Length:565
Mass (Da):62,450
Last modified:July 10, 2007 - v1
Checksum:iF06375A1B1FE06A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA. Translation: ABQ81057.1.
RefSeqiWP_012053940.1. NC_009512.1.

Genome annotation databases

EnsemblBacteriaiABQ81057; ABQ81057; Pput_4937.
KEGGippf:Pput_4937.

Similar proteinsi

Entry informationi

Entry nameiBETA_PSEP1
AccessioniPrimary (citable) accession number: A5WA97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families