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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei199NADUniRule annotation1
Binding sitei251NADUniRule annotation1
Binding sitei300NADUniRule annotation1
Binding sitei375NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 167NADUniRule annotation3
Nucleotide bindingi228 – 233NADUniRule annotation6
Nucleotide bindingi321 – 323NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Pput_4849
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247521 – 469AdenosylhomocysteinaseAdd BLAST469

Proteomic databases

PRIDEiA5WA09.

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_4849.

Structurei

3D structure databases

ProteinModelPortaliA5WA09.
SMRiA5WA09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WA09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAANMPAGF TDYKVADISL AAWGRRETII AESEMPALMG LRRKYLAEQP
60 70 80 90 100
LKGAKILGCI HMTIQTAVLI ETLVALGAEV RWSSCNIFST QDQAAASIAA
110 120 130 140 150
AGIPVFAWKG ETEEEYEWCL EQTILKDGQP WDANMILDDG GDLTELLHKK
160 170 180 190 200
YPQVLDRVHG VTEETTTGVH RLLDMLAKGE LKVPAINVND SVTKSKNDNK
210 220 230 240 250
YGCRHSLNDA IKRGTDHLLS GKQALVIGYG DVGKGSAQSL RQEGMIVKVS
260 270 280 290 300
EVDPICAMQA CMDGFELVSP FIDGINDGTE ASIDKALLGK IDLIVTTTGN
310 320 330 340 350
VNVCDANMLK ALKKRAVVCN IGHFDNEIDT AFMRKNWAWE EVKPQVHKVH
360 370 380 390 400
RTGAGSFDPQ NDDYLILLAE GRLVNLGNAT GHPSRIMDGS FANQVLAQIF
410 420 430 440 450
LFEQKFADLP AEKKAERLTV EVLPKKLDEE VALEMVRGFG GVVTQLTKQQ
460
ADYIGVTVEG PFKPHAYRY
Length:469
Mass (Da):51,447
Last modified:July 10, 2007 - v1
Checksum:iFEFD3BF43E4A01A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA. Translation: ABQ80969.1.
RefSeqiWP_012053902.1. NC_009512.1.

Genome annotation databases

EnsemblBacteriaiABQ80969; ABQ80969; Pput_4849.
KEGGippf:Pput_4849.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PSEP1
AccessioniPrimary (citable) accession number: A5WA09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families