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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei317 – 3171Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciPPUT351746:GI26-4123-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Pput_4040
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000021617Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_4040.

Structurei

3D structure databases

ProteinModelPortaliA5W7Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP. Bacteria.
COG2038. LUCA.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

A5W7Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQAWWRDAC QPLDNAAMDQ ARARQQQLTK PAGSLGQLEA LAIQLAGLQG
60 70 80 90 100
LERPTLDQVA ITIFAGDHGV VEEGISAYPQ AVTGQMLCNF VGGGAAISVL
110 120 130 140 150
ARQLQASLDV VDLGTIDAQL ELPGVRHLRL GTGTANFARQ PAMTENQLQA
160 170 180 190 200
ALQAGRDSAQ RGAEQGAQLF IGGEMGIGNT TAAAALASVL LGCPASELSG
210 220 230 240 250
PGTGLDNAGV QHKAEVIERA LRLHGLRAED PLQVLGCVGG FEIAALVGAY
260 270 280 290 300
IGCAQAGVAV LVDGFICSVA ALVAVRLNPQ CRAWLLFAHQ GAEPGHKTLL
310 320 330 340 350
AALQAEPLLA LGLRLGEGSG AALAVPLLRL ACALHGQMAT FAEAAVADRP

A
Length:351
Mass (Da):36,012
Last modified:July 10, 2007 - v1
Checksum:iA01038C85D362EBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA. Translation: ABQ80164.1.
RefSeqiWP_012053448.1. NC_009512.1.

Genome annotation databases

EnsemblBacteriaiABQ80164; ABQ80164; Pput_4040.
KEGGippf:Pput_4040.
PATRICi19924305. VBIPsePut56420_4103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA. Translation: ABQ80164.1.
RefSeqiWP_012053448.1. NC_009512.1.

3D structure databases

ProteinModelPortaliA5W7Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351746.Pput_4040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ80164; ABQ80164; Pput_4040.
KEGGippf:Pput_4040.
PATRICi19924305. VBIPsePut56420_4103.

Phylogenomic databases

eggNOGiENOG4105CUP. Bacteria.
COG2038. LUCA.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.
BioCyciPPUT351746:GI26-4123-MONOMER.

Family and domain databases

CDDicd02439. DMB-PRT_CobT. 1 hit.
Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT. 1 hit.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOBT_PSEP1
AccessioniPrimary (citable) accession number: A5W7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.