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A5W6F5 (STHA_PSEP1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1
Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]
Gene names
Name:sthA
Ordered Locus Names:Pput_3591
OrganismPseudomonas putida (strain F1 / ATCC 700007) [Complete proteome] [HAMAP]
Taxonomic identifier351746 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247

Catalytic activity

NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_00247

Subcellular location

Cytoplasm By similarity HAMAP MF_00247.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+ transhydrogenase (B-specific) activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
PRO_1000012565

Regions

Nucleotide binding35 – 4410FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5W6F5 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 6A86683818494616

FASTA46450,906
        10         20         30         40         50         60 
MAVYNYDVVV LGSGPAGEGA AMNAAKAGRK VAMVDDRRQV GGNCTHLGTI PSKALRHSVR 

        70         80         90        100        110        120 
QIMQFNTNPM FRAIGEPRWF SFPDVLKSAE KVIAKQVASR TGYYARNRVD VFVGTGSFAD 

       130        140        150        160        170        180 
EQTVEVVCPN GVVEKLNAKH IIIATGSRPY RPADIDFHHP RVYDSDTILS LSHTPRKLIV 

       190        200        210        220        230        240 
YGAGVIGCEY ASIFSGLGVL VELVDNRGQL LSFLDSEISQ ALSYHFSNNN ITVRHNEEYE 

       250        260        270        280        290        300 
RVEGLDNGVI LHLKSGKKIK ADALLWCNGR TGNTDKLGLE NIGIKVNSRG QIEVDEAYRT 

       310        320        330        340        350        360 
TVPNIYGAGD VIGWPSLASA AHDQGRSAAG SIVDNGSWRF VNDVPTGIYT IPEISSIGKN 

       370        380        390        400        410        420 
EQELTQAKVP YEVGKAFFKS MARAQIAGEP QGMLKILFHR ETLEILGVHC FGYQASEIVH 

       430        440        450        460 
IGQAIMNQPG EQNNLKYFVN TTFNYPTMAE AYRVAAYDGL NRLF

« Hide

References

[1]"Complete sequence of Pseudomonas putida F1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Parales R., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F1 / ATCC 700007.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000712 Genomic DNA. Translation: ABQ79715.1.
RefSeqYP_001268899.1. NC_009512.1.

3D structure databases

ProteinModelPortalA5W6F5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5W6F5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5192190.
GenomeReviewsGene locus Pput_3591 in contig CP000712_GR.
KEGGppf:Pput_3591.
PATRIC19923335. VBIPsePut56420_3639.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHBG515043.
OMAGEGNTIE.
ProtClustDBPRK05249.

Enzyme and pathway databases

BioCycPPUT351746:PPUT_3591-MONOMER.

Family and domain databases

HAMAPMF_00247. SthA.
[Tree]
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR022962. STH.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00322.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSTHA_PSEP1
AccessionPrimary (citable) accession number: A5W6F5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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