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A5W4F9 (ACDH2_PSEP1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Ordered Locus Names:Pput_2889
OrganismPseudomonas putida (strain F1 / ATCC 700007) [Complete proteome] [HAMAP]
Taxonomic identifier351746 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387708

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2911NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5W4F9 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 8493107A6E2138DD

FASTA31433,141
        10         20         30         40         50         60 
MQTHDGKTAV AIIGSGNIGT DLMVKILRHG KHLRMGAFVG IDPESDGLKR AERMGVPTVS 

        70         80         90        100        110        120 
TGIEGLLSHP DFGSIGFVFD ATSAGAHARH EQLLRPHGVR VIDLTPAAIG PFVVPAVNIE 

       130        140        150        160        170        180 
QHLDAPNVNM VTCGGQATIP MVAAVSRVVP VEYAEIVASI SSRSAGPGTR ANIDEFTETT 

       190        200        210        220        230        240 
SNAIVRVGGA QRGKAIIILN PAEPPLIMRD TVYCLVPGHA DRQAIVESVE RMASAVAAYV 

       250        260        270        280        290        300 
PGYRLKQTVQ FDEFKGRMPQ ETGSAQAPRL KVSVFLEVEG AGHYLPSYAG NLDIMTSAAL 

       310 
ATAERIAARQ PVAA 

« Hide

References

[1]"Complete sequence of Pseudomonas putida F1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., Parales R., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F1 / ATCC 700007.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000712 Genomic DNA. Translation: ABQ79019.1.
RefSeqYP_001268203.1. NC_009512.1.

3D structure databases

ProteinModelPortalA5W4F9.
SMRA5W4F9. Positions 7-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351746.Pput_2889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ79019; ABQ79019; Pput_2889.
GeneID5192958.
KEGGppf:Pput_2889.
PATRIC19921921. VBIPsePut56420_2945.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHARHEQL.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycPPUT351746:GI26-2937-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_PSEP1
AccessionPrimary (citable) accession number: A5W4F9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families