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A5W4F9

- ACDH2_PSEP1

UniProt

A5W4F9 - ACDH2_PSEP1

Protein

Acetaldehyde dehydrogenase 2

Gene

Pput_2889

Organism
Pseudomonas putida (strain F1 / ATCC 700007)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
    Binding sitei291 – 2911NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi164 – 1729NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPPUT351746:GI26-2937-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:Pput_2889
    OrganismiPseudomonas putida (strain F1 / ATCC 700007)
    Taxonomic identifieri351746 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000006553: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Acetaldehyde dehydrogenase 2PRO_0000387708Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351746.Pput_2889.

    Structurei

    3D structure databases

    ProteinModelPortaliA5W4F9.
    SMRiA5W4F9. Positions 7-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHARHEQL.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5W4F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTHDGKTAV AIIGSGNIGT DLMVKILRHG KHLRMGAFVG IDPESDGLKR    50
    AERMGVPTVS TGIEGLLSHP DFGSIGFVFD ATSAGAHARH EQLLRPHGVR 100
    VIDLTPAAIG PFVVPAVNIE QHLDAPNVNM VTCGGQATIP MVAAVSRVVP 150
    VEYAEIVASI SSRSAGPGTR ANIDEFTETT SNAIVRVGGA QRGKAIIILN 200
    PAEPPLIMRD TVYCLVPGHA DRQAIVESVE RMASAVAAYV PGYRLKQTVQ 250
    FDEFKGRMPQ ETGSAQAPRL KVSVFLEVEG AGHYLPSYAG NLDIMTSAAL 300
    ATAERIAARQ PVAA 314
    Length:314
    Mass (Da):33,141
    Last modified:July 10, 2007 - v1
    Checksum:i8493107A6E2138DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000712 Genomic DNA. Translation: ABQ79019.1.
    RefSeqiYP_001268203.1. NC_009512.1.

    Genome annotation databases

    EnsemblBacteriaiABQ79019; ABQ79019; Pput_2889.
    GeneIDi5192958.
    KEGGippf:Pput_2889.
    PATRICi19921921. VBIPsePut56420_2945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000712 Genomic DNA. Translation: ABQ79019.1 .
    RefSeqi YP_001268203.1. NC_009512.1.

    3D structure databases

    ProteinModelPortali A5W4F9.
    SMRi A5W4F9. Positions 7-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351746.Pput_2889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ79019 ; ABQ79019 ; Pput_2889 .
    GeneIDi 5192958.
    KEGGi ppf:Pput_2889.
    PATRICi 19921921. VBIPsePut56420_2945.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HARHEQL.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci PPUT351746:GI26-2937-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F1 / ATCC 700007.

    Entry informationi

    Entry nameiACDH2_PSEP1
    AccessioniPrimary (citable) accession number: A5W4F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3