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Protein

Acetaldehyde dehydrogenase 2

Gene

Pput_2889

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Acyl-thioester intermediateUniRule annotation1
Binding sitei291NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18NADUniRule annotation4
Nucleotide bindingi164 – 172NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciPPUT351746:GI26-2892-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Pput_2889
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877081 – 314Acetaldehyde dehydrogenase 2Add BLAST314

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_2889.

Structurei

3D structure databases

ProteinModelPortaliA5W4F9.
SMRiA5W4F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiMIKVIRH.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A5W4F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTHDGKTAV AIIGSGNIGT DLMVKILRHG KHLRMGAFVG IDPESDGLKR
60 70 80 90 100
AERMGVPTVS TGIEGLLSHP DFGSIGFVFD ATSAGAHARH EQLLRPHGVR
110 120 130 140 150
VIDLTPAAIG PFVVPAVNIE QHLDAPNVNM VTCGGQATIP MVAAVSRVVP
160 170 180 190 200
VEYAEIVASI SSRSAGPGTR ANIDEFTETT SNAIVRVGGA QRGKAIIILN
210 220 230 240 250
PAEPPLIMRD TVYCLVPGHA DRQAIVESVE RMASAVAAYV PGYRLKQTVQ
260 270 280 290 300
FDEFKGRMPQ ETGSAQAPRL KVSVFLEVEG AGHYLPSYAG NLDIMTSAAL
310
ATAERIAARQ PVAA
Length:314
Mass (Da):33,141
Last modified:July 10, 2007 - v1
Checksum:i8493107A6E2138DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA. Translation: ABQ79019.1.
RefSeqiWP_012052608.1. NC_009512.1.

Genome annotation databases

EnsemblBacteriaiABQ79019; ABQ79019; Pput_2889.
KEGGippf:Pput_2889.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH2_PSEP1
AccessioniPrimary (citable) accession number: A5W4F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families