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Protein

Acetaldehyde dehydrogenase 1

Gene

Pput_2874

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Acyl-thioester intermediateUniRule annotation1
Binding sitei291NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:Pput_2874
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001870381 – 316Acetaldehyde dehydrogenase 1Add BLAST316

Proteomic databases

PRIDEiA5W4E5

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_2874

Structurei

3D structure databases

ProteinModelPortaliA5W4E5
SMRiA5W4E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A5W4E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKVKAAII GSGNIGTDLM IKILRHGQHI EMGAMVGIDP ASDGLARAQR
60 70 80 90 100
MGVAITHEGV EGLTRLPVFN EIDVVFDATS AGAHVKNEAL LRERKPGLRM
110 120 130 140 150
IDLTPAAIGP YCIPVVNGDD HLDATNVNMV TCGGQATIPM VAAVSRVAKV
160 170 180 190 200
HYAEIIASIS SKSAGPGTRA NIDEFTETTS KAIEVVGGAA KGKAIIVLNP
210 220 230 240 250
AEPPLMMRDT VYTLSDFADI DQIEESVQRM ADAVQAYVPG YRLKQRVQFD
260 270 280 290 300
RIEADCPIRI PGVGDRMNGL KTSIFLEVEG AAHYLPAYAG NLDIMTSAAL
310
RTAEKLAERL LASLVA
Length:316
Mass (Da):33,685
Last modified:July 10, 2007 - v1
Checksum:i8EC4DB2D9A44D19B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA Translation: ABQ79005.1
RefSeqiWP_012052594.1, NC_009512.1

Genome annotation databases

EnsemblBacteriaiABQ79005; ABQ79005; Pput_2874
KEGGippf:Pput_2874

Similar proteinsi

Entry informationi

Entry nameiACDH1_PSEP1
AccessioniPrimary (citable) accession number: A5W4E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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