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A5W348

- GCH4_PSEP1

UniProt

A5W348 - GCH4_PSEP1

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Pput_2420
Organism
Pseudomonas putida (strain F1 / ATCC 700007)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPPUT351746:GI26-2468-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Pput_2420
OrganismiPseudomonas putida (strain F1 / ATCC 700007)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000006553: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314GTP cyclohydrolase FolE2UniRule annotation
PRO_0000316533Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_2420.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5W348-1 [UniParc]FASTAAdd to Basket

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MSSALPDVSV TDLTHSLSPL QWVGMQGIDL PVRIEEPTYQ RELHARADVQ    50
VDLPAPHVKG IHMSRLYCLL DAWGQAAAVS PASLFALLQE MIDSHQDCGS 100
RNARLRLDFD LLVRRPALVT EGLSGWKSYS VHVLATKVGG ALNLSIEVRI 150
GYSSTCPCSA ALSRQLIEDG FLRTFKDQPL LEASAVAQWL RSNASLATPH 200
SQRSEARVRV TVPSDAPDLG LLALIDQVEG ALRTPVQTAV KRADEQAFAA 250
LNGQNLMFVE DAARRIQASL RGYRDSQVHV RHLESLHPHD ASAWSAPQAS 300
APDQQESFAT GNER 314
Length:314
Mass (Da):34,307
Last modified:May 5, 2009 - v2
Checksum:i4E09C943A9E59870
GO

Sequence cautioni

The sequence ABQ78558.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000712 Genomic DNA. Translation: ABQ78558.1. Different initiation.
RefSeqiYP_001267742.1. NC_009512.1.

Genome annotation databases

EnsemblBacteriaiABQ78558; ABQ78558; Pput_2420.
GeneIDi5195436.
KEGGippf:Pput_2420.
PATRICi19920973. VBIPsePut56420_2469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000712 Genomic DNA. Translation: ABQ78558.1 . Different initiation.
RefSeqi YP_001267742.1. NC_009512.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 351746.Pput_2420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ78558 ; ABQ78558 ; Pput_2420 .
GeneIDi 5195436.
KEGGi ppf:Pput_2420.
PATRICi 19920973. VBIPsePut56420_2469.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PPUT351746:GI26-2468-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F1 / ATCC 700007.

Entry informationi

Entry nameiGCH4_PSEP1
AccessioniPrimary (citable) accession number: A5W348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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