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A5W348

- GCH4_PSEP1

UniProt

A5W348 - GCH4_PSEP1

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas putida (strain F1 / ATCC 700007)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPPUT351746:GI26-2468-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Pput_2420
    OrganismiPseudomonas putida (strain F1 / ATCC 700007)
    Taxonomic identifieri351746 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000006553: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314GTP cyclohydrolase FolE2PRO_0000316533Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351746.Pput_2420.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiQNLMYVE.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    IPR000048. IQ_motif_EF-hand-BS.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5W348-1 [UniParc]FASTAAdd to Basket

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    MSSALPDVSV TDLTHSLSPL QWVGMQGIDL PVRIEEPTYQ RELHARADVQ    50
    VDLPAPHVKG IHMSRLYCLL DAWGQAAAVS PASLFALLQE MIDSHQDCGS 100
    RNARLRLDFD LLVRRPALVT EGLSGWKSYS VHVLATKVGG ALNLSIEVRI 150
    GYSSTCPCSA ALSRQLIEDG FLRTFKDQPL LEASAVAQWL RSNASLATPH 200
    SQRSEARVRV TVPSDAPDLG LLALIDQVEG ALRTPVQTAV KRADEQAFAA 250
    LNGQNLMFVE DAARRIQASL RGYRDSQVHV RHLESLHPHD ASAWSAPQAS 300
    APDQQESFAT GNER 314
    Length:314
    Mass (Da):34,307
    Last modified:May 5, 2009 - v2
    Checksum:i4E09C943A9E59870
    GO

    Sequence cautioni

    The sequence ABQ78558.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000712 Genomic DNA. Translation: ABQ78558.1. Different initiation.
    RefSeqiYP_001267742.1. NC_009512.1.

    Genome annotation databases

    EnsemblBacteriaiABQ78558; ABQ78558; Pput_2420.
    GeneIDi5195436.
    KEGGippf:Pput_2420.
    PATRICi19920973. VBIPsePut56420_2469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000712 Genomic DNA. Translation: ABQ78558.1 . Different initiation.
    RefSeqi YP_001267742.1. NC_009512.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351746.Pput_2420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ78558 ; ABQ78558 ; Pput_2420 .
    GeneIDi 5195436.
    KEGGi ppf:Pput_2420.
    PATRICi 19920973. VBIPsePut56420_2469.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi QNLMYVE.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PPUT351746:GI26-2468-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    IPR000048. IQ_motif_EF-hand-BS.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F1 / ATCC 700007.

    Entry informationi

    Entry nameiGCH4_PSEP1
    AccessioniPrimary (citable) accession number: A5W348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3