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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADUniRule annotation1
Binding sitei82SubstrateUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei95NADUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6
Nucleotide bindingi118 – 120NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciPPUT351746:G1G90-718-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Pput_0687
OrganismiPseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Taxonomic identifieri351746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000006553 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916521 – 309Malate dehydrogenaseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi351746.Pput_0687

Structurei

3D structure databases

ProteinModelPortaliA5VY92
SMRiA5VY92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

A5VY92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLTIVGAG LVGEAAAQII ARDELCRELV LMDVQGELAQ GKALDVWQAA
60 70 80 90 100
VDSGSDTHVH GGAKAEMLEG SELVVITAGV PRKPGQSRQD VLSTNLPILD
110 120 130 140 150
SIMADIKHHA PTATVLVVSN PVDVLTYRAW SVSGQGRDKV FGQAGVLDTA
160 170 180 190 200
RMKCFIAEQT GFSARDITAL VLGGHGDSMV PLMRYCQIGS VPLSHFLSSE
210 220 230 240 250
QIEQIVERTR KGGGEILGLK KTGSACDAPG VAIAQMVDAI GNGRNRILPA
260 270 280 290 300
VAILEGEYGR TDIAMGVPCV LAEKGLARVI ELPLDAQEQA MFDHSADQVA

RDIAEMKAL
Length:309
Mass (Da):32,656
Last modified:July 10, 2007 - v1
Checksum:iB512BB03B4EFEE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000712 Genomic DNA Translation: ABQ76852.1
RefSeqiWP_012051139.1, NC_009512.1

Genome annotation databases

EnsemblBacteriaiABQ76852; ABQ76852; Pput_0687
KEGGippf:Pput_0687

Similar proteinsi

Entry informationi

Entry nameiMDH_PSEP1
AccessioniPrimary (citable) accession number: A5VY92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health