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A5VV25

- GCSP_BRUO2

UniProt

A5VV25 - GCSP_BRUO2

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBOVI444178:GH2V-2773-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BOV_A0679
    OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
    Taxonomic identifieri444178 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000006383: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 932932Glycine dehydrogenase (decarboxylating)PRO_1000045567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei685 – 6851N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi444178.BOV_A0679.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VV25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5VV25-1 [UniParc]FASTAAdd to Basket

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    MTEFLPFVAR HIGPRHEDER AMLAALGLPS METLITQAVP ASIRLNRALN    50
    LPAALSEADA LAELGTIMGR NVVKKSFIGA GYHGVHTPPV IQRNLFENPA 100
    WYTAYTPYQS EISQGRLELL FHFQTLVAEL TGLPVACASL LDEATAVAEA 150
    IGVACRHHRD KRSRILLAGE LHPQTVDVVN TRAEPLGWEI ATGSDVDDNT 200
    AAIVVPWPDT RGVYGDFAKV IADAKAKGAL VIAVADPLAL TIMEAPARWG 250
    ADMAVGSMQR YGVPMGFGGP HAAYLAVSEV LTRIIPGRIV GQSVDAHGRA 300
    AYRLALQTRE QHIRRDKATS NICTAQALLA NMAAAFAIWH GPAGLQAIAM 350
    RVAALAARFA AALKAAGVEI AGESLFDTVT AKVPGKAAAI AAEADKGGRL 400
    IRIIDTDTVG VTFDETSTEE DLTALASLFG TKPVGGDTVL VPGKERGEGF 450
    LTQEVFHSHR SETEMMRFLR RLADKDLALD RAMIPLGSCT MKLNAAAEMM 500
    PVSWNTVANL HPFAPAEQVQ GYAKMTSDLE AWLCEITGFA GVSLQPNAGS 550
    QGEYAGLMAI RHYHQARGQG HRNICLIPSS AHGTNPASAS MAGMSVVVVN 600
    CRPDGDIDID DLKAKAEKHR DNLAAFMITY PSTYGVFEEG IKAFCEIVHD 650
    NGGQVYFDGA NLNALVGLAR PADIGADVCH MNLHKTFCIP HGGGGPGVGP 700
    IGVAKHLVPY LPGHVEAGSE HAVAAAQFGS ASILVITWMY IRMMGGAGLK 750
    KATEAAILNA NYIAHRLKGV YPILYTGAHD RVAHECIVDT RVLKDSAGIT 800
    VEDVAKRLID YGFHAPTMSW PVAGTLMIEP TESEPKLEID RLCDAMIAIA 850
    GEAKKVADGV WPADDNPLAN APHTASDTLA TEWKHPYTRA EAIFPGGAFD 900
    PTAKYWPPVS RVDNVGGDRN LICSCPPVAA YG 932
    Length:932
    Mass (Da):99,298
    Last modified:July 10, 2007 - v1
    Checksum:i901F425F7E9A5AB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000709 Genomic DNA. Translation: ABQ62542.1.
    RefSeqiYP_001257680.1. NC_009504.1.

    Genome annotation databases

    EnsemblBacteriaiABQ62542; ABQ62542; BOV_A0679.
    GeneIDi5203257.
    KEGGibov:BOV_A0679.
    PATRICi17858683. VBIBruOvi136990_0781.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000709 Genomic DNA. Translation: ABQ62542.1 .
    RefSeqi YP_001257680.1. NC_009504.1.

    3D structure databases

    ProteinModelPortali A5VV25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444178.BOV_A0679.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ62542 ; ABQ62542 ; BOV_A0679 .
    GeneIDi 5203257.
    KEGGi bov:BOV_A0679.
    PATRICi 17858683. VBIBruOvi136990_0781.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BOVI444178:GH2V-2773-MONOMER.

    Miscellaneous databases

    PROi A5VV25.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Paulsen I.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25840 / 63/290 / NCTC 10512.

    Entry informationi

    Entry nameiGCSP_BRUO2
    AccessioniPrimary (citable) accession number: A5VV25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3