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Protein

Malate dehydrogenase

Gene

mdh

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.IEP:

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.IEP:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADIEP:1
Binding sitei83SubstrateIEP:1
Binding sitei89SubstrateIEP:1
Binding sitei96NADIEP:1
Binding sitei121SubstrateIEP:1
Binding sitei152SubstrateIEP:1
Active sitei176Proton acceptorIEP:1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADIEP:6
Nucleotide bindingi119 – 121NADIEP:3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseIEP: (EC:1.1.1.37IEP:)
Gene namesi
Name:mdhIEP:
Ordered Locus Names:BOV_1856
OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Taxonomic identifieri444178 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000006383 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264681 – 320Malate dehydrogenaseAdd BLAST320

Structurei

3D structure databases

ProteinModelPortaliA5VSQ4.
SMRiA5VSQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.IEP:

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiICIIANP.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VSQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNKIALIG SGMIGGTLAH LAGLKELGDV VLFDIAEGTP QGKGLDIAES
60 70 80 90 100
SPVDGFDAKF TGANDYAAIE GADVVIVTAG VPRKPGMSRD DLLGINLKVM
110 120 130 140 150
EQVGAGIKKY APEAFVICIT NPLDAMVWAL QKFSGLPAHK VVGMAGVLDS
160 170 180 190 200
ARFRYFLSEE FNVSVEDVTA FVLGGHGDSM VPLARYSTVA GIPLPDLVKM
210 220 230 240 250
GWTSQDKLDK IIQRTRDGGA EIVGLLKTGS AFYAPAASAI QMAESYLKDK
260 270 280 290 300
KRVLPVAAQL SGQYGVKDMY VGVPTVIGAN GVERIIEIDL DKDEKAQFDK
310 320
SVASVAGLCE ACIGIAPSLK
Length:320
Mass (Da):33,676
Last modified:July 10, 2007 - v1
Checksum:iFD73DD88E6557FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000708 Genomic DNA. Translation: ABQ61517.1.
RefSeqiWP_004686256.1. NC_009505.1.

Genome annotation databases

EnsemblBacteriaiABQ61517; ABQ61517; BOV_1856.
KEGGibov:BOV_1856.

Similar proteinsi

Entry informationi

Entry nameiMDH_BRUO2
AccessioniPrimary (citable) accession number: A5VSQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families