ID   CTRA_BRUO2              Reviewed;         232 AA.
AC   A5VRW9;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=Cell cycle response regulator CtrA;
GN   Name=ctrA; OrderedLocusNames=BOV_1542;
OS   Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=444178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25840 / 63/290 / NCTC 10512;
RX   PubMed=19436743; DOI=10.1371/journal.pone.0005519;
RA   Tsolis R.M., Seshadri R., Santos R.L., Sangari F.J., Lobo J.M.,
RA   de Jong M.F., Ren Q., Myers G., Brinkac L.M., Nelson W.C., Deboy R.T.,
RA   Angiuoli S., Khouri H., Dimitrov G., Robinson J.R., Mulligan S.,
RA   Walker R.L., Elzer P.E., Hassan K.A., Paulsen I.T.;
RT   "Genome degradation in Brucella ovis corresponds with narrowing of its host
RT   range and tissue tropism.";
RL   PLoS ONE 4:E5519-E5519(2009).
RN   [2]
RP   PROTEIN EXPRESSION.
RX   PubMed=11929544; DOI=10.1046/j.1365-2958.2002.02777.x;
RA   Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J.,
RA   Letesson J.J., De Bolle X.;
RT   "Plasticity of a transcriptional regulation network among alpha-
RT   proteobacteria is supported by the identification of CtrA targets in
RT   Brucella abortus.";
RL   Mol. Microbiol. 43:945-960(2002).
CC   -!- FUNCTION: Essential protein that plays a role in the control of cell
CC       division, possibly through the transcriptional regulation of ccrM,
CC       rpoD, pleC, minC and ftsZ genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CP000708; ABQ60383.1; -; Genomic_DNA.
DR   RefSeq; WP_002964699.1; NC_009505.1.
DR   AlphaFoldDB; A5VRW9; -.
DR   SMR; A5VRW9; -.
DR   GeneID; 58775378; -.
DR   KEGG; bov:BOV_1542; -.
DR   HOGENOM; CLU_000445_30_1_5; -.
DR   PhylomeDB; A5VRW9; -.
DR   Proteomes; UP000006383; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd17616; REC_OmpR_CtrA; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 6.10.250.690; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR   PANTHER; PTHR48111:SF35; TRANSCRIPTIONAL REGULATORY PROTEIN QSEB; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..232
FT                   /note="Cell cycle response regulator CtrA"
FT                   /id="PRO_0000363200"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..223
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   232 AA;  26066 MW;  9177C2281EC76ACE CRC64;
     MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY
     EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK
     GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
//