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Reviewed, UniProtKB/Swiss-Prot A5VRH5 (MURB_BRUO2)

Last modified November 3, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase
Gene names
Name: murB
Ordered Locus Names: BOV_1386
OrganismBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) [Complete proteome] [HAMAP]
Taxonomic identifier444178 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

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Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the murB family.

Contains 1 FAD-binding PCMH-type domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_1000002867

Regions

Domain36 – 202167FAD-binding PCMH-type

Sites

Active site1821 By similarity
Active site2311Proton donor By similarity
Active site3011 By similarity

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Sequences

Sequence LengthMass (Da)Tools
A5VRH5-1 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 35079AE908CE76D5

FASTA32234,891
        10         20         30         40         50         60 
MMESGEALLK KLDGRLSGLR GRLTPDTGMD KITWFRAGGP AQVLFQPSDE EDLSAFLKAV 

        70         80         90        100        110        120 
PEEIPLLVVG IGSNLLVRDG GVPGFVVRLS AKGFGEVEQV CDTQLRAGAA APDKRVAAAA 

       130        140        150        160        170        180 
LEAGLAGFHF YHGIPGGIGG ALRMNAGANG VETRERVVEV RALDRKGEVH VLSNADMGYA 

       190        200        210        220        230        240 
YRHSSASPDL IFTSVLFEGV PGERDDIRRA MDEVQHHRET VQPVREKTGG STFKNPEGTS 

       250        260        270        280        290        300 
AWKEIDKAGC RGLRVGGAQM SEMHCNFMIN TGNATGHDLE TLGETVRARV FENSGIRLHW 

       310        320 
EIKRLGLFRE GEQIEEFLGK IV

« Hide

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References

[1]Paulsen I.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000708 Genomic DNA. Translation: ABQ61769.1.
RefSeqYP_001259322.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5201954.
GenomeReviewsGene locus BOV_1386 in contig CP000708_GR.
KEGGbov:BOV_1386.
TIGRBOV_1386.

Phylogenomic databases

OMAQPIREKT.

Family and domain databases

HAMAPMF_00037.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMURB_BRUO2
AccessionPrimary (citable) accession number: A5VRH5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents