Reviewed, UniProtKB/Swiss-Prot A5VPX1 (ARGC_BRUO2)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BOV_0783

Organism

Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) [Complete proteome] [HAMAP]

Taxonomic identifier

444178 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000065140
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5VPX1-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 43274AC79823BF4F	FASTA	310	33,744
	10 20 30 40 50 60 MKPKIFIDGE HGTTGLQIRT RLAERDDLEV ISIPEAERRN KDLRADYLRA ADIAILCLPD 70 80 90 100 110 120 DASKEAVSLL EGHNSTRIID TSTAHRVHPD WAYGFAELAK GQRERIAEAR LVANPGCYPT 130 140 150 160 170 180 GAIALVRPLC DAGLLPADYP VSVNAVSGYT GGGKQLIAQM EDRNHPDYLA ANNFLYGLPL 190 200 210 220 230 240 KHKHVPELQL HGRLDRRPIF SPSVGRFPQG MIVQVPLFLS ELEGSPSLAK VHAVLTEHYA 250 260 270 280 290 300 GQDIVEVVPL EESAKLPRVD AEELAGKDGM KLFVFGTEDH GQVNLVALLD NLGKGASGAA 310 VQNMNLMLGK

References

[1]	Paulsen I. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000708 Genomic DNA. Translation: ABQ61374.1.
RefSeq	YP_001258768.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5202374.
GenomeReviews	Gene locus BOV_0783 in contig CP000708_GR.
KEGG	bov:BOV_0783.
TIGR	BOV_0783.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	PIFVPSV.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR010136. AGPR_subtype. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. argC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BRUO2

Accession

Primary (citable) accession number: A5VPX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 10, 2007
Last modified:	February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)