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A5VPA6

- BETA_BRUO2

UniProt

A5VPA6 - BETA_BRUO2

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBOVI444178:GH2V-552-MONOMER.
RETL1328306-WGS:GSTH-5720-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:BOV_0554
OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Taxonomic identifieri444178 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000006383: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000046558Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444178.BOV_0554.

Structurei

3D structure databases

ProteinModelPortaliA5VPA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VPA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS
60 70 80 90 100
FPMNMETYDW GFSSEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAC
110 120 130 140 150
DFDHWSQSGA RGWAYADVLP YFKRMENSQG GQEGWRGTNG PLYVQRGKRD
160 170 180 190 200
NPLFHAFVEA GHQAGFEVTD DYNGEKQEGF GPMEQTIHNG RRWSAANAYL
210 220 230 240 250
KPALKRPNVK LVKGFARKIV LEGKRAVGVE IEAGRTFSTI RARREVIIAA
260 270 280 290 300
SSINSPKLLM LSGIGPAAHL KEHGIDLVAD RPGVGQNLQD HLEVYIQQEC
310 320 330 340 350
TQPITLYSKL NLFSKARIGV EWLLFKTGDG ATNHFESAAF VRSKAGVEYP
360 370 380 390 400
DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP
410 420 430 440 450
VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFDPYRGAEI QPGAHVQTDD
460 470 480 490 500
EIDNFIREHV ESAFHPCGTC KMGAVDDPMA VVDPECRVIG VEGLRVADSS
510 520 530 540
IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSNQEPWI NPRWQVSDR
Length:549
Mass (Da):60,623
Last modified:July 10, 2007 - v1
Checksum:iBBAF18D5428B5372
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000708 Genomic DNA. Translation: ABQ61350.1.
RefSeqiYP_001258553.1. NC_009505.1.

Genome annotation databases

EnsemblBacteriaiABQ61350; ABQ61350; BOV_0554.
GeneIDi5201855.
KEGGibov:BOV_0554.
PATRICi17860922. VBIBruOvi136990_1879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000708 Genomic DNA. Translation: ABQ61350.1 .
RefSeqi YP_001258553.1. NC_009505.1.

3D structure databases

ProteinModelPortali A5VPA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444178.BOV_0554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ61350 ; ABQ61350 ; BOV_0554 .
GeneIDi 5201855.
KEGGi bov:BOV_0554.
PATRICi 17860922. VBIBruOvi136990_1879.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BOVI444178:GH2V-552-MONOMER.
RETL1328306-WGS:GSTH-5720-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Paulsen I.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25840 / 63/290 / NCTC 10512.

Entry informationi

Entry nameiBETA_BRUO2
AccessioniPrimary (citable) accession number: A5VPA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3