ID   BETB_BRUO2              Reviewed;         487 AA.
AC   A5VPA5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=BOV_0553;
OS   Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=444178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Paulsen I.;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000708; ABQ61307.1; -; Genomic_DNA.
DR   RefSeq; YP_001258552.1; -.
DR   GeneID; 5201875; -.
DR   GenomeReviews; CP000708_GR; BOV_0553.
DR   KEGG; bov:BOV_0553; -.
DR   TIGR; BOV_0553; -.
DR   OMA; A5VPA5; VFKPSEN.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR011264; Betaine_Ald_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047030.
FT   NP_BIND     227    232       NAD (By similarity).
FT   ACT_SITE    249    249       By similarity.
FT   ACT_SITE    283    283       By similarity.
SQ   SEQUENCE   487 AA;  52035 MW;  E4B8F2DFC983A654 CRC64;
     MKAQPKASHF IGGAFVEDKA GKPLPVIYPA TGEEIASLYS ATPGIIEAAY AAALKAQGEW
     AALKPVERGR ILRRTAEILR EKNRKLSKLE TLDTGKALQE TLVADAASAA DALEFFGGII
     SGFNGEFVEL GGSFAYTRRE ALGICVGIGA WNYPIQIAAW KSAPALAMGN AFIFKPSENT
     PLSALALAEA YKEAGLPDGL FNVVQGYGDV GAALVNHRLT AKVSLTGSVP TGRRIMAQAG
     EQLKHVTMEL GGKSPLIVFD DADLESAIGG AMLGNFYSTG QVCSNGTRVF VHKNIRERFI
     ERLVERTRKI RIGDPFDEAT QMGPLISAAQ RDKVLSYIKK GKAEGATLAC GGGVPKLQGF
     DKGFFIEPTV FADVTDTMTI AREEIFGPVM SVLEFSDEDE VIARANDSEF GLAAGVFTAD
     LSRGHHVIGQ IKAGTCWINA YNLTPVEVPF GGYKQSGIGR ENGIAALAHY SQIKTVYVEM
     GKVDSPY
//