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A5VP58

- MTB1_BRUO2

UniProt

A5VP58 - MTB1_BRUO2

Protein

Modification methylase BabI

Gene

ccrM

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBOVI444178:GH2V-493-MONOMER.

    Protein family/group databases

    REBASEi15978. M.BovORF495P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase BabI (EC:2.1.1.72)
    Short name:
    M.BabI
    Alternative name(s):
    Adenine-specific methyltransferase BabI
    DNA methyltransferase CcrM
    M.CcrMI ortholog
    Gene namesi
    Name:ccrM
    Synonyms:babI
    Ordered Locus Names:BOV_0495
    OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
    Taxonomic identifieri444178 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000006383: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Modification methylase BabIPRO_0000363192Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444178.BOV_0495.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VP58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VP58-1 [UniParc]FASTAAdd to Basket

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    MRSQVIEYPM SLVRLAHELP IEAPRTAWLD SIIKGDCVSA LERLPDHSVD    50
    VIFADPPYNL QLGGDLHRPD QSMVSAVDDH WDQFESFQAY DAFTRAWLLA 100
    CRRVLKPNGT IWVIGSYHNI FRVGTQLQDL GFWLLNDIVW RKTNPMPNFR 150
    GRRFQNAHET LIWASRDQKG KGYTFNYEAM KAANDDVQMR SDWLFPICTG 200
    SERLKDENGD KVHPTQKPEA LLARIMMASS KPGDVILDPF FGSGTTGAVA 250
    KRLGRHFVGI EREQPYIDAA TARINAVEPL GKAELTVMTG KRAEPRVAFT 300
    SVMEAGLLRP GTVLCDERRR FAAIVRADGT LTANGEAGSI HRIGARVQGF 350
    DACNGWTFWH FEENGVLKPI DALRKIIREQ MAAAGA 386
    Length:386
    Mass (Da):43,292
    Last modified:July 10, 2007 - v1
    Checksum:i8662138DB587B6CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000708 Genomic DNA. Translation: ABQ61978.1.
    RefSeqiYP_001258505.1. NC_009505.1.

    Genome annotation databases

    EnsemblBacteriaiABQ61978; ABQ61978; BOV_0495.
    GeneIDi5201802.
    KEGGibov:BOV_0495.
    PATRICi17860791. VBIBruOvi136990_1813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000708 Genomic DNA. Translation: ABQ61978.1 .
    RefSeqi YP_001258505.1. NC_009505.1.

    3D structure databases

    ProteinModelPortali A5VP58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444178.BOV_0495.

    Protein family/group databases

    REBASEi 15978. M.BovORF495P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ61978 ; ABQ61978 ; BOV_0495 .
    GeneIDi 5201802.
    KEGGi bov:BOV_0495.
    PATRICi 17860791. VBIBruOvi136990_1813.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci BOVI444178:GH2V-493-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Paulsen I.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25840 / 63/290 / NCTC 10512.

    Entry informationi

    Entry nameiMTB1_BRUO2
    AccessioniPrimary (citable) accession number: A5VP58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3