Reviewed, UniProtKB/Swiss-Prot A5VP46 (KHSE_BRUO2)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BOV_0481

Organism

Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) [Complete proteome] [HAMAP]

Taxonomic identifier

444178 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_1000022576

Sequences

	Sequence		Length	Mass (Da)
	A5VP46-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: E3B0264713512E37	FASTA	326	36,574
	10 20 30 40 50 60 MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 70 80 90 100 110 120 DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 130 140 150 160 170 180 VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVEQGLVAET EADLDFLEKN 190 200 210 220 230 240 WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 250 260 270 280 290 300 RTKGAALLRG YTSVRPLSEA EADALPVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 310 320 YVRGMRFHRQ IESAAEYGLE MQEVAA

References

[1]	Paulsen I. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000708 Genomic DNA. Translation: ABQ61511.1.
RefSeq	YP_001258493.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5202477.
GenomeReviews	Gene locus BOV_0481 in contig CP000708_GR.
KEGG	bov:BOV_0481.
TIGR	BOV_0481.
Phylogenomic databases
OMA	ADLFRDN.
Family and domain databases
HAMAP	MF_00301. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BRUO2

Accession

Primary (citable) accession number: A5VP46

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)