Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5VLS3 (HEMH_LACRD) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Lreu_1554
OrganismLactobacillus reuteri (strain DSM 20016) [Complete proteome] [HAMAP]
Taxonomic identifier557436 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Ferrochelatase HAMAP MF_00323
PRO_1000059483

Sites

Metal binding1841Iron By similarity
Metal binding2651Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A5VLS3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: C4A5EAD080FE7FBD

FASTA31035,387
        10         20         30         40         50         60 
MKKNGLLLVN LGSPDTPTTP DVKRYLKEFL SDRNVIEMPP ALWQPLLRGI ILPTRSWRSA 

        70         80         90        100        110        120 
TFYRNCWTKD GSPLIVYTER LVAKVQGLMP EWVVKMAMTY GKPKISDTIT GMKKECQNIT 

       130        140        150        160        170        180 
VLPLFPFFTK STTQTVIDKV KDADPEAKII DRFSAEEDYL DLLAKQIQTA WDRGKYDKLL 

       190        200        210        220        230        240 
ISYHGIPTAM VNHGDPYRDE TEAATAELIK RLDIPEKQIK MAYQSKFGPM PWLKPYLRNT 

       250        260        270        280        290        300 
LLNEAQLGHR DVLVVAPSFV ADCLETLEED QVQNYQVFRE NGGNNLVMVP SLNDSPEFAQ 

       310 
FITDLVQRKG

« Hide

References

[1]"The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri."
Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M., Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M., Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L. expand/collapse author list , Ivanova N., Kyrpides N.C., Walter J.
PLoS Genet. 7:E1001314-E1001314(2011) [PubMed: 21379339] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 20016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000705 Genomic DNA. Translation: ABQ83797.1.
RefSeqYP_001272134.1. NC_009513.1.

3D structure databases

ProteinModelPortalA5VLS3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5VLS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5188273.
GenomeReviewsGene locus Lreu_1554 in contig CP000705_GR.
KEGGlre:Lreu_1554.
PATRIC22256363. VBILacReu87937_1570.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK821272.

Enzyme and pathway databases

BioCycLREU557436:LREU_1554-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LACRD
AccessionPrimary (citable) accession number: A5VLS3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents