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A5VL28

- SYL_LACRD

UniProt

A5VL28 - SYL_LACRD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei581 – 5811ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLREU557436:GC7Y-1358-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Lreu_1295
    OrganismiLactobacillus reuteri (strain DSM 20016)
    Taxonomic identifieri557436 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001991: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_1000057345Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557436.Lreu_1295.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VL28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi578 – 5825"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VL28-1 [UniParc]FASTAAdd to Basket

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    MAYDHKTIEK KWQKFWKKNE TFKADLNKDQ KKYYALDMFP YPSGQGLHVG    50
    HPEGYTATDV MSRMKRMQGF NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT 100
    NKNIDHFRDQ IQSLGFSYDW DREVNTTDPK FYKWTQWIFE QLYKKGLAYE 150
    SEIMVNWAPD FMGGTVVANE EVEDGKTKRG GYPVYRKPMR QWVLKITAYA 200
    DRLIDDLDLV DWPESVKEMQ RNWIGRSEGA SVFFPVVGDE DTKIEVFTTR 250
    ADTLFGASYV VLAPEQELVD QLTTPEHKAE VEKYKEEASR RSDLERTDLN 300
    KDKTGVFTGS YVINPVNGEK LPIWISDYVL ASYGTGAVMA VPSGDQRDYD 350
    FATKFNLPIK PIIEGADISE GAFDGDGKHI NSGFLDGLNI ADAKQKMIDW 400
    LEEHDAGHKK VNYRLRDWIF SRQRYWGEPI PVIHWDDGTT SLVPEDELPL 450
    ELPKTDNIEP SGTGESPLAN VEDWVNVYDE NGRHGLRETN TMPQWAGSSW 500
    YWLRYTDPHN DEEFASKEAL DYWSPVDLYV GGAEHAVLHL LYARFWHKVL 550
    YDLGLVPTKE PFMKLVNQGM ILGSNHEKMS KSKGNVVNPD DIVDQYGADT 600
    LRLYEMFMGP LEESVPWDEK GLHGANKWVQ RVWRLLMDDN NHLRDRVSTF 650
    NDGKLTKVYN QTVKKVTEDY ERMHFNTAIS QLMVFVNEAY KVDDLPVEYM 700
    KGFVKMIAPI MPHMAEELWS QFGESDTITY QPWPTYDPKA LVEDEVEMIV 750
    QVNGKVRAKI KMAKDTDRDE AQQLALANEH VKKFTDGKDI KKVIVVPNKI 800
    VNIVAK 806
    Length:806
    Mass (Da):92,919
    Last modified:July 10, 2007 - v1
    Checksum:i08383790E3207E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ83552.1.
    RefSeqiWP_003668546.1. NC_009513.1.
    YP_001271889.1. NC_009513.1.

    Genome annotation databases

    EnsemblBacteriaiABQ83552; ABQ83552; Lreu_1295.
    GeneIDi5188374.
    KEGGilre:Lreu_1295.
    PATRICi22255798. VBILacReu87937_1309.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ83552.1 .
    RefSeqi WP_003668546.1. NC_009513.1.
    YP_001271889.1. NC_009513.1.

    3D structure databases

    ProteinModelPortali A5VL28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557436.Lreu_1295.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ83552 ; ABQ83552 ; Lreu_1295 .
    GeneIDi 5188374.
    KEGGi lre:Lreu_1295.
    PATRICi 22255798. VBILacReu87937_1309.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LREU557436:GC7Y-1358-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20016.

    Entry informationi

    Entry nameiSYL_LACRD
    AccessioniPrimary (citable) accession number: A5VL28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3