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A5VJK9

- TYSY_LACRD

UniProt

A5VJK9 - TYSY_LACRD

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Protein

Thymidylate synthase

Gene

thyA

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciLREU557436:GC7Y-816-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:Lreu_0769
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001991: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Thymidylate synthasePRO_0000321469Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi557436.Lreu_0769.

Structurei

3D structure databases

ProteinModelPortaliA5VJK9.
SMRiA5VJK9. Positions 7-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VJK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATNVNEEQY LDLIRYVLAN GHQKGDRTGT GTKSVFGYQM RFDLSKGFPI
60 70 80 90 100
LTTKKVPFGL IKSELLWFLR GDTNIRFLLQ HKNHIWDEWA FKKWVESDEY
110 120 130 140 150
QGPDMTDFGH RWLKDPEFKQ VYLQEKKAFC QRILEDDDFA QKYGDLGLVY
160 170 180 190 200
GSQWRKWKTS QGDTIDQIAN VIQQIKTTPD SRRMIVSAWN PEDVPSMALP
210 220 230 240 250
PCHTMFQFYV NDGKLSCQLY QRSADIFLGV PFNIASYALL THMIAHQCGL
260 270 280 290 300
EPGEFVHTLG DAHIYLNHLD QVKEQLTRTP HEAPKLILPA EPKPIDQYEM
310 320
TDIKLEGYTH EPAIKAPVAV
Length:320
Mass (Da):36,982
Last modified:July 10, 2007 - v1
Checksum:iC50E1CE992A306EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ83033.1.
RefSeqiYP_001271370.1. NC_009513.1.

Genome annotation databases

EnsemblBacteriaiABQ83033; ABQ83033; Lreu_0769.
GeneIDi5188966.
KEGGilre:Lreu_0769.
PATRICi22254713. VBILacReu87937_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ83033.1 .
RefSeqi YP_001271370.1. NC_009513.1.

3D structure databases

ProteinModelPortali A5VJK9.
SMRi A5VJK9. Positions 7-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557436.Lreu_0769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ83033 ; ABQ83033 ; Lreu_0769 .
GeneIDi 5188966.
KEGGi lre:Lreu_0769.
PATRICi 22254713. VBILacReu87937_0783.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci LREU557436:GC7Y-816-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20016.

Entry informationi

Entry nameiTYSY_LACRD
AccessioniPrimary (citable) accession number: A5VJK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3