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A5VJH1

- ASSY_LACRD

UniProt

A5VJH1 - ASSY_LACRD

Protein

Argininosuccinate synthase

Gene

argG

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei174 – 1741CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLREU557436:GC7Y-778-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Lreu_0731
    OrganismiLactobacillus reuteri (strain DSM 20016)
    Taxonomic identifieri557436 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001991: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Argininosuccinate synthasePRO_1000057039Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi557436.Lreu_0731.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VJH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VJH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKEKIVLAY SGGLDTSVAI AWLKNKGYDV IACCIDVGEG KDLEAIKEKG    50
    LQVGAWKSVV IDAKRDFAEQ FVLPALQAHA MYEQKYPLVS ALSRPLIVQK 100
    LVAVANQYGA TAIAHGCTGK GNDQVRFEAG IHALAPEMKI EDPIRDWHWS 150
    REEEIQYAKD NGIPVPITKA SPYSIDENLW GRANECGILE DPWAAAPADA 200
    YDRTVSIEEA PDTPTTIEIT FNEGVPTAID GEEMPLDQLI MKLDKLAGSH 250
    GIGRIDHVEN RLVGIKSREI YECPAATVLL AAHKDLEDLT QEREVAHFKP 300
    LIEQKMSGII YNGLWYSPLM KSLVAFIDES QAVVNGVVRV KLFKGNVICE 350
    GRKSPNSLYD KNLATYTSAD EFDQEAATGF IKLWELPDKV YAQVQNKNKK 400
    KVKENTSDAY 410
    Length:410
    Mass (Da):45,395
    Last modified:July 10, 2007 - v1
    Checksum:iEF62608A1AFC3D92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ82995.1.
    RefSeqiWP_011953439.1. NC_009513.1.
    YP_001271332.1. NC_009513.1.

    Genome annotation databases

    EnsemblBacteriaiABQ82995; ABQ82995; Lreu_0731.
    GeneIDi5189344.
    KEGGilre:Lreu_0731.
    PATRICi22254637. VBILacReu87937_0745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ82995.1 .
    RefSeqi WP_011953439.1. NC_009513.1.
    YP_001271332.1. NC_009513.1.

    3D structure databases

    ProteinModelPortali A5VJH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557436.Lreu_0731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ82995 ; ABQ82995 ; Lreu_0731 .
    GeneIDi 5189344.
    KEGGi lre:Lreu_0731.
    PATRICi 22254637. VBILacReu87937_0745.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci LREU557436:GC7Y-778-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20016.

    Entry informationi

    Entry nameiASSY_LACRD
    AccessioniPrimary (citable) accession number: A5VJH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3