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A5VJ71

- DEF_LACRD

UniProt

A5VJ71 - DEF_LACRD

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Protein

Peptide deformylase

Gene
def, Lreu_0630
Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131Iron By similarity
Metal bindingi156 – 1561Iron By similarity
Active sitei157 – 1571 By similarity
Metal bindingi160 – 1601Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLREU557436:GC7Y-676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:Lreu_0630
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001991: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Peptide deformylaseUniRule annotationPRO_1000058244Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557436.Lreu_0630.

Structurei

3D structure databases

ProteinModelPortaliA5VJ71.
SMRiA5VJ71. Positions 1-181.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiSQDPKIA.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VJ71-1 [UniParc]FASTAAdd to Basket

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MYLMKDITRD GNPVLRKRAA KVSFPLSDED QKLAKDMMKY LEVSQDPELC    50
KKYKLRAGVG LAAPQVGVSK QMAAVLVPAP DEDEKPLFKD VIINPVIVSE 100
SVQYGALTEG EGCLSVDKDV PGYVPRHDRI TLRYQDVNGE THKVRLKHYP 150
AIVCQHEIDH LHGVLFYDHI NKDQPFEAPA DTVMIS 186
Length:186
Mass (Da):20,898
Last modified:July 10, 2007 - v1
Checksum:iE2D4ACC7B46888BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82895.1.
RefSeqiYP_001271232.1. NC_009513.1.

Genome annotation databases

EnsemblBacteriaiABQ82895; ABQ82895; Lreu_0630.
GeneIDi5189677.
KEGGilre:Lreu_0630.
PATRICi22254435. VBILacReu87937_0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82895.1 .
RefSeqi YP_001271232.1. NC_009513.1.

3D structure databases

ProteinModelPortali A5VJ71.
SMRi A5VJ71. Positions 1-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557436.Lreu_0630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ82895 ; ABQ82895 ; Lreu_0630 .
GeneIDi 5189677.
KEGGi lre:Lreu_0630.
PATRICi 22254435. VBILacReu87937_0645.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi SQDPKIA.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci LREU557436:GC7Y-676-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20016.

Entry informationi

Entry nameiDEF_LACRD
AccessioniPrimary (citable) accession number: A5VJ71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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