A5VJ54 (A5VJ54_LACRD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Ordered Locus Names:

Lreu_0611

Organism

Lactobacillus reuteri (strain DSM 20016) [Complete proteome] [HAMAP] EMBL ABQ82878.1

Taxonomic identifier

557436 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus reuteri

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. RuleBase RU004249 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. RuleBase RU004249 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. RuleBase RU004249
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 EMBL ABQ82878.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: UniProtKB-UniPathway threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5VJ54 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 069C8A9127E33C8C	FASTA	452	50,121
	10 20 30 40 50 60 MKVVKFGGSS LANGEAFQNA INIITSDPQR RVIVTSAPGK RFADDIKVTD LLIKYAQTVI 70 80 90 100 110 120 AGQNPQEIVE QILNRYQEIA AYFGLPADKL IPLAERLEGL PNHTYPNDNY LLAAFKAHGE 130 140 150 160 170 180 RLNAQLMAIL LQHLGYEARF VTPSEAGIIV TGTPNNANVI PETYANLSHF TFNENELLIF 190 200 210 220 230 240 PGFYGLTLAG HIATFSRGGS DITGAILARG LHASTYENFT DVDAIYSANP QIVDHPQPIT 250 260 270 280 290 300 TMTYREMREL SYAGFSVFHD EALIPAIQGN IPINVRNTND PEKPGTMIVP DKDFQPSDIV 310 320 330 340 350 360 TGVVSGKHFA ALYLHKYLLN KQAGFTLRIL EILAKHNVSY EHMPSGIDDI TIILDRNAIN 370 380 390 400 410 420 DQLIDTICNE IQEEINPDRL EWIDNYAITM VVGEGMRNRT GVIDDILMPL AEKHIAVPMI 430 440 450 NQGASRIAIM IGTYNEDADE AVRAIYHRFF AN

References

[1]

"The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri." Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M., Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M., Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L. , Ivanova N., Kyrpides N.C., Walter J. PLoS Genet. 7:E1001314-E1001314(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 20016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000705 Genomic DNA. Translation: ABQ82878.1.
RefSeq	YP_001271215.1. NC_009513.1.
3D structure databases
ProteinModelPortal	A5VJ54.
ModBase	Search...
Protein-protein interaction databases
STRING	557436.Lreu_0611.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ82878; ABQ82878; Lreu_0611.
GeneID	5188819.
KEGG	lre:Lreu_0611.
PATRIC	22254397. VBILacReu87937_0626.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0527.
HOGENOM	HOG000293095.
KO	K00928.
OMA	YLHRYLL.
ProtClustDB	PRK09034.
Enzyme and pathway databases
UniPathway	UPA00034; UER00015. UPA00050; UER00461. UPA00051; UER00462.
Family and domain databases
Gene3D	3.40.1160.10. 2 hits.
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5VJ54_LACRD

Accession

Primary (citable) accession number: A5VJ54

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)