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Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Proton acceptorUniRule annotation1
Metal bindingi143ZincUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi85 – 88ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Lreu_0451Imported
OrganismiLactobacillus reuteri (strain DSM 20016)Imported
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001991 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5VIP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiKEQFGWI.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VIP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLFFKYGA MNSGKSIDIL KVAHNYEEQG KPVVLMTSGV DDRSGRGIIA
60 70 80 90 100
SRIGLERKVK PIMDDTNIYD YVNKMDRKIY CVLIDEAQFL KKEHVLQLIK
110 120 130 140 150
IVDELNIPVM AFGLKNDFRN ELFEGSKYLL IYADKIEEMK TICWFCPHKA
160 170 180 190
TMNLRIHNGK PVYEGEQVQI GGNESYYPVC RKHYFHPQLK Q
Length:191
Mass (Da):22,171
Last modified:July 10, 2007 - v1
Checksum:i56A1541E23FACF45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA. Translation: ABQ82719.1.
RefSeqiWP_003667548.1. NZ_AZDD01000022.1.

Genome annotation databases

EnsemblBacteriaiABQ82719; ABQ82719; Lreu_0451.
GeneIDi5188855.
KEGGilre:Lreu_0451.
PATRICifig|557436.17.peg.857.

Similar proteinsi

Entry informationi

Entry nameiA5VIP5_LACRD
AccessioniPrimary (citable) accession number: A5VIP5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported