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A5VIM0 (OTC_LACRD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:Lreu_0425
OrganismLactobacillus reuteri (strain DSM 20016) [Complete proteome] [HAMAP]
Taxonomic identifier557436 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm By similarity HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Ornithine carbamoyltransferase HAMAP MF_01109
PRO_1000084846

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region273 – 2764Ornithine binding By similarity

Sites

Binding site1081Carbamoyl phosphate By similarity
Binding site1351Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
A5VIM0 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: D21F29753A992210

FASTA33537,560
        10         20         30         40         50         60 
MAFNLRNRSF LTLADFNTRE MEYMLDLAED LKKAKYAGYE GKNLKGKNIA LIFEKSSTRT 

        70         80         90        100        110        120 
RCSFEVGAKD EGAHVTYLGP SGSHIGHKES VKDTARVLGG MFDGIEYRGF SQRNVEILAK 

       130        140        150        160        170        180 
YSGVPVWNGL TDEDHPTQVL ADFLTAHEVL KKPYKDIKFA FVGDGQDNVS NALMLGAAVM 

       190        200        210        220        230        240 
GMEYHVVTPK ELEPTKETLD KANEIAAKTG AKIVVTNDIK EGVKGMDVIY ADVWVSMGES 

       250        260        270        280        290        300 
DDMWEKRINL LKPYQVTMDV MKATENPNVL FEHCLPAFHN LDTEVGKEIE KKFGLKEMEV 

       310        320        330 
TDEVFESEHS VVFREAENRM HTIKAVMVAT LGEQN

« Hide

References

[1]"The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri."
Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M., Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M., Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L. expand/collapse author list , Ivanova N., Kyrpides N.C., Walter J.
PLoS Genet. 7:E1001314-E1001314(2011) [PubMed: 21379339] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 20016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000705 Genomic DNA. Translation: ABQ82694.1.
RefSeqYP_001271031.1. NC_009513.1.

3D structure databases

ProteinModelPortalA5VIM0.
SMRA5VIM0. Positions 2-333.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5VIM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5188926.
GenomeReviewsGene locus Lreu_0425 in contig CP000705_GR.
KEGGlre:Lreu_0425.
PATRIC22253959. VBILacReu87937_0438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMADFRIFAP.
ProtClustDBPRK04284.

Enzyme and pathway databases

BioCycLREU557436:LREU_0425-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_LACRD
AccessionPrimary (citable) accession number: A5VIM0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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