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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110NAD; via amide nitrogenUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Binding sitei145NAD; via amide nitrogenUniRule annotation1
Active sitei196Proton acceptorUniRule annotation1
Binding sitei260NADUniRule annotation1
Binding sitei286NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:Lreu_0371
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001991 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000607861 – 338Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST338

Proteomic databases

PRIDEiA5VIG6

Structurei

3D structure databases

ProteinModelPortaliA5VIG6
SMRiA5VIG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 261Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

A5VIG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKIAVLGA GSWGSVLANM LTENGHDVTL WSRNEEQVKQ LNTEHTNPRY
60 70 80 90 100
MKDFVYSTNL TATTDMKKAV KGASVVLIVI PTKGLREVAK QLNAILTELH
110 120 130 140 150
QKPLVIHATK GLEQNTYKRP SEMLSEDISP ENRQAIVVLS GPSHAEDVAI
160 170 180 190 200
KDMTAVTAAC EDLASAKKAQ KLFSNSYFRV YTNDDVIGAE FGAALKNIIA
210 220 230 240 250
IGAGAIQGLG YHDNARAALI TRGLAEIRRL GVAFGANPMT FIGLSGVGDL
260 270 280 290 300
VVTATSKNSR NWRAGYQLGQ GKKLQDVIDN MGMVIEGVYT TKAAYELSRK
310 320 330
RQVQMPITEA LYRVLYEGED IKTAISQLMD RDLTSENE
Length:338
Mass (Da):36,905
Last modified:July 10, 2007 - v1
Checksum:i6DE17A10B166CD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA Translation: ABQ82640.1
RefSeqiWP_003667443.1, NZ_AZDD01000014.1

Genome annotation databases

EnsemblBacteriaiABQ82640; ABQ82640; Lreu_0371
GeneIDi5189746
KEGGilre:Lreu_0371
PATRICifig|557436.17.peg.411

Similar proteinsi

Entry informationi

Entry nameiGPDA_LACRD
AccessioniPrimary (citable) accession number: A5VIG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health