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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Lreu_0142
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001991 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000621611 – 345Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST345

Structurei

3D structure databases

ProteinModelPortaliA5VHU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYQDAGVD VNAGYELVHR IKDAVKSTDR PGVIGGIGSF GGMFDLEKLQ
60 70 80 90 100
VQHPILVSGT DGVGTKLLIA QQMNKHDTIG IDVVAMCVND VLAQGAEPIT
110 120 130 140 150
FLDYIATGHN DPAKMAAIVS GVATGCREAG AALIGGETAE MPDMYAANEY
160 170 180 190 200
DLAGTVTGIA EKEELLTTAG PQKGDILLGL PSSGLHSNGF SLVRQILFKD
210 220 230 240 250
NHVKLTDRPE ALRGKTVGET ILTPTRIYVQ AVLPLVHRKL VHGISHITGG
260 270 280 290 300
GLIENVPRML GDNLQAVIDP GRWPQLPVFD YLRVLGGLTK EDCFEAFNMG
310 320 330 340
IGMVLAVAPD QVAQVQEILS NKNMTSYQIG YLRHCLPDTK KIVIK
Length:345
Mass (Da):36,976
Last modified:July 10, 2007 - v1
Checksum:iD10AF7073B1133CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA. Translation: ABQ82414.1.
RefSeqiWP_003669727.1. NZ_AZDD01000012.1.

Genome annotation databases

EnsemblBacteriaiABQ82414; ABQ82414; Lreu_0142.
GeneIDi5190126.
KEGGilre:Lreu_0142.
PATRICi22253348. VBILacReu87937_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA. Translation: ABQ82414.1.
RefSeqiWP_003669727.1. NZ_AZDD01000012.1.

3D structure databases

ProteinModelPortaliA5VHU0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ82414; ABQ82414; Lreu_0142.
GeneIDi5190126.
KEGGilre:Lreu_0142.
PATRICi22253348. VBILacReu87937_0148.

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPUR5_LACRD
AccessioniPrimary (citable) accession number: A5VHU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.