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A5VHU0

- PUR5_LACRD

UniProt

A5VHU0 - PUR5_LACRD

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLREU557436:GC7Y-142-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Lreu_0142
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001991: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000062161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557436.Lreu_0142.

Structurei

3D structure databases

ProteinModelPortaliA5VHU0.
SMRiA5VHU0. Positions 16-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VHU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRYQDAGVD VNAGYELVHR IKDAVKSTDR PGVIGGIGSF GGMFDLEKLQ
60 70 80 90 100
VQHPILVSGT DGVGTKLLIA QQMNKHDTIG IDVVAMCVND VLAQGAEPIT
110 120 130 140 150
FLDYIATGHN DPAKMAAIVS GVATGCREAG AALIGGETAE MPDMYAANEY
160 170 180 190 200
DLAGTVTGIA EKEELLTTAG PQKGDILLGL PSSGLHSNGF SLVRQILFKD
210 220 230 240 250
NHVKLTDRPE ALRGKTVGET ILTPTRIYVQ AVLPLVHRKL VHGISHITGG
260 270 280 290 300
GLIENVPRML GDNLQAVIDP GRWPQLPVFD YLRVLGGLTK EDCFEAFNMG
310 320 330 340
IGMVLAVAPD QVAQVQEILS NKNMTSYQIG YLRHCLPDTK KIVIK
Length:345
Mass (Da):36,976
Last modified:July 10, 2007 - v1
Checksum:iD10AF7073B1133CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82414.1.
RefSeqiWP_003669727.1. NC_009513.1.
YP_001270751.1. NC_009513.1.

Genome annotation databases

EnsemblBacteriaiABQ82414; ABQ82414; Lreu_0142.
GeneIDi5190126.
KEGGilre:Lreu_0142.
PATRICi22253348. VBILacReu87937_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82414.1 .
RefSeqi WP_003669727.1. NC_009513.1.
YP_001270751.1. NC_009513.1.

3D structure databases

ProteinModelPortali A5VHU0.
SMRi A5VHU0. Positions 16-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557436.Lreu_0142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ82414 ; ABQ82414 ; Lreu_0142 .
GeneIDi 5190126.
KEGGi lre:Lreu_0142.
PATRICi 22253348. VBILacReu87937_0148.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LREU557436:GC7Y-142-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20016.

Entry informationi

Entry nameiPUR5_LACRD
AccessioniPrimary (citable) accession number: A5VHU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3