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A5VHS9

- FTHS_LACRD

UniProt

A5VHS9 - FTHS_LACRD

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Lreu_0131
Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLREU557436:GC7Y-131-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Lreu_0131
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001991: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557436.Lreu_0131.

Structurei

3D structure databases

ProteinModelPortaliA5VHS9.
SMRiA5VHS9. Positions 3-551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VHS9-1 [UniParc]FASTAAdd to Basket

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MTDIEIADQA TLEPITEIAE KLGLSEDEIE QYGKYKAKID LNVKPLPDKK    50
HKLILVTSIN PTPAGEGKST VLIGLGDALN QLNYQTTIAM REPSMGPVFG 100
IKGGATGGGY SQVVPMEDIN LNFTGDLHAL TSANNTLAAL IDNYIMRDNA 150
MNLDPRRIIW KRVEDVNDRA LRNVVTGLGG PMAGVPRETG FDITAASELM 200
AILCLSTSLH DLKERISRIV VGYTYDKEPV TVGQLNFQDA ITIILKDALK 250
PNLVQTLDHT PTIVHGGPFA NIAHGCNSVL ATQTALNLSD YTVTEAGFGA 300
DLGGEKFLDI KQRVLGKHPD AIVIVATVRA LEYNGGAKLA DLNEENLDAL 350
KKGMANLNRH IKNMQLYGLP IVVAINHFVS DTDKEIQMIK DDCAKQNVEA 400
ILTDAWAKGG KGTHDLANKV VELADSPSEF THIYDVQVDD LQTKLEKIAK 450
QIYGAKEVSF SRKAQNQLKR FAKYGWNDLP VCIAKTQYSF TDDQKQLGAP 500
TDFTFHIREL VPKIGAGFVV ALAGNMMTMP GLPKEPAAVN MMIDDNGKIT 550
GLF 553
Length:553
Mass (Da):60,252
Last modified:July 10, 2007 - v1
Checksum:i191BBFE9E0FB534D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82403.1.
RefSeqiYP_001270740.1. NC_009513.1.

Genome annotation databases

EnsemblBacteriaiABQ82403; ABQ82403; Lreu_0131.
GeneIDi5189700.
KEGGilre:Lreu_0131.
PATRICi22253326. VBILacReu87937_0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000705 Genomic DNA. Translation: ABQ82403.1 .
RefSeqi YP_001270740.1. NC_009513.1.

3D structure databases

ProteinModelPortali A5VHS9.
SMRi A5VHS9. Positions 3-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557436.Lreu_0131.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ82403 ; ABQ82403 ; Lreu_0131 .
GeneIDi 5189700.
KEGGi lre:Lreu_0131.
PATRICi 22253326. VBILacReu87937_0137.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LREU557436:GC7Y-131-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20016.

Entry informationi

Entry nameiFTHS_LACRD
AccessioniPrimary (citable) accession number: A5VHS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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