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A5VHS9

- FTHS_LACRD

UniProt

A5VHS9 - FTHS_LACRD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 698ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLREU557436:GC7Y-131-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Lreu_0131
    OrganismiLactobacillus reuteri (strain DSM 20016)
    Taxonomic identifieri557436 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001991: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_1000068790Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557436.Lreu_0131.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VHS9.
    SMRiA5VHS9. Positions 3-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VHS9-1 [UniParc]FASTAAdd to Basket

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    MTDIEIADQA TLEPITEIAE KLGLSEDEIE QYGKYKAKID LNVKPLPDKK    50
    HKLILVTSIN PTPAGEGKST VLIGLGDALN QLNYQTTIAM REPSMGPVFG 100
    IKGGATGGGY SQVVPMEDIN LNFTGDLHAL TSANNTLAAL IDNYIMRDNA 150
    MNLDPRRIIW KRVEDVNDRA LRNVVTGLGG PMAGVPRETG FDITAASELM 200
    AILCLSTSLH DLKERISRIV VGYTYDKEPV TVGQLNFQDA ITIILKDALK 250
    PNLVQTLDHT PTIVHGGPFA NIAHGCNSVL ATQTALNLSD YTVTEAGFGA 300
    DLGGEKFLDI KQRVLGKHPD AIVIVATVRA LEYNGGAKLA DLNEENLDAL 350
    KKGMANLNRH IKNMQLYGLP IVVAINHFVS DTDKEIQMIK DDCAKQNVEA 400
    ILTDAWAKGG KGTHDLANKV VELADSPSEF THIYDVQVDD LQTKLEKIAK 450
    QIYGAKEVSF SRKAQNQLKR FAKYGWNDLP VCIAKTQYSF TDDQKQLGAP 500
    TDFTFHIREL VPKIGAGFVV ALAGNMMTMP GLPKEPAAVN MMIDDNGKIT 550
    GLF 553
    Length:553
    Mass (Da):60,252
    Last modified:July 10, 2007 - v1
    Checksum:i191BBFE9E0FB534D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ82403.1.
    RefSeqiYP_001270740.1. NC_009513.1.

    Genome annotation databases

    EnsemblBacteriaiABQ82403; ABQ82403; Lreu_0131.
    GeneIDi5189700.
    KEGGilre:Lreu_0131.
    PATRICi22253326. VBILacReu87937_0137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000705 Genomic DNA. Translation: ABQ82403.1 .
    RefSeqi YP_001270740.1. NC_009513.1.

    3D structure databases

    ProteinModelPortali A5VHS9.
    SMRi A5VHS9. Positions 3-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557436.Lreu_0131.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ82403 ; ABQ82403 ; Lreu_0131 .
    GeneIDi 5189700.
    KEGGi lre:Lreu_0131.
    PATRICi 22253326. VBILacReu87937_0137.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LREU557436:GC7Y-131-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20016.

    Entry informationi

    Entry nameiFTHS_LACRD
    AccessioniPrimary (citable) accession number: A5VHS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3