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A5VGU5

- ACDH3_SPHWW

UniProt

A5VGU5 - ACDH3_SPHWW

Protein

Acetaldehyde dehydrogenase 3

Gene

Swit_4924

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
    Binding sitei288 – 2881NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi160 – 1689NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-5267-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
    Gene namesi
    Ordered Locus Names:Swit_4924
    Encoded oniPlasmid pSWIT020 Publication
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Plasmid pSWIT02

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Acetaldehyde dehydrogenase 3PRO_0000387744Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_4924.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VGU5.
    SMRiA5VGU5. Positions 3-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiIPEDADH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5VGU5-1 [UniParc]FASTAAdd to Basket

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    MGKKKVAIIG SGNIGTDLMI KVMRLSEVLE MGVMVGIDPA SDGLARAARM    50
    GVATTHKGID GLLAMPEFAD VEIVFDATSA GAHKRNSELV LAAGKRMIDL 100
    TPAAIGPYVI PPVNGDKCLD ALNVNMVTCG GQATIPIVAA VNRVAKVHYG 150
    EIIASIASKS AGPGTRANID EFTETTSQAI MDVGGATRGK AIIILNPAEP 200
    PLIMRDTVYC LCEDADQEAI RQSIHDMVAE VQSYVPGYRL KQAVQFEHIG 250
    SNRPLQIPEM DGEYTGLKVS VFLEVEGAAH YLPSYAGNLD IMTSAAMKTA 300
    EKIAARMHEG ATT 313
    Length:313
    Mass (Da):33,107
    Last modified:July 10, 2007 - v1
    Checksum:i53BA565325C87A3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000701 Genomic DNA. Translation: ABQ71544.1.
    RefSeqiYP_001260311.1. NC_009508.1.

    Genome annotation databases

    EnsemblBacteriaiABQ71544; ABQ71544; Swit_4924.
    GeneIDi5196010.
    KEGGiswi:Swit_4924.
    PATRICi23678647. VBISphWit55028_0300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000701 Genomic DNA. Translation: ABQ71544.1 .
    RefSeqi YP_001260311.1. NC_009508.1.

    3D structure databases

    ProteinModelPortali A5VGU5.
    SMRi A5VGU5. Positions 3-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_4924.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ71544 ; ABQ71544 ; Swit_4924 .
    GeneIDi 5196010.
    KEGGi swi:Swit_4924.
    PATRICi 23678647. VBISphWit55028_0300.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi IPEDADH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci SWIT392499:GHZK-5267-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273.

    Entry informationi

    Entry nameiACDH3_SPHWW
    AccessioniPrimary (citable) accession number: A5VGU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3