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Protein

Acetaldehyde dehydrogenase 3

Gene

Swit_4924

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
Binding sitei288 – 2881NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi160 – 1689NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-5267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Swit_4924
Encoded oniPlasmid pSWIT020 Publication
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989 Componenti: Plasmid pSWIT02

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Acetaldehyde dehydrogenase 3PRO_0000387744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA5VGU5.
SMRiA5VGU5. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiTSAGAHR.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VGU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKKVAIIG SGNIGTDLMI KVMRLSEVLE MGVMVGIDPA SDGLARAARM
60 70 80 90 100
GVATTHKGID GLLAMPEFAD VEIVFDATSA GAHKRNSELV LAAGKRMIDL
110 120 130 140 150
TPAAIGPYVI PPVNGDKCLD ALNVNMVTCG GQATIPIVAA VNRVAKVHYG
160 170 180 190 200
EIIASIASKS AGPGTRANID EFTETTSQAI MDVGGATRGK AIIILNPAEP
210 220 230 240 250
PLIMRDTVYC LCEDADQEAI RQSIHDMVAE VQSYVPGYRL KQAVQFEHIG
260 270 280 290 300
SNRPLQIPEM DGEYTGLKVS VFLEVEGAAH YLPSYAGNLD IMTSAAMKTA
310
EKIAARMHEG ATT
Length:313
Mass (Da):33,107
Last modified:July 10, 2007 - v1
Checksum:i53BA565325C87A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000701 Genomic DNA. Translation: ABQ71544.1.
RefSeqiWP_011950822.1. NC_009508.1.
YP_001260311.1. NC_009508.1.

Genome annotation databases

EnsemblBacteriaiABQ71544; ABQ71544; Swit_4924.
KEGGiswi:Swit_4924.
PATRICi23678647. VBISphWit55028_0300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000701 Genomic DNA. Translation: ABQ71544.1.
RefSeqiWP_011950822.1. NC_009508.1.
YP_001260311.1. NC_009508.1.

3D structure databases

ProteinModelPortaliA5VGU5.
SMRiA5VGU5. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ71544; ABQ71544; Swit_4924.
KEGGiswi:Swit_4924.
PATRICi23678647. VBISphWit55028_0300.

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiTSAGAHR.
OrthoDBiEOG6H1PXH.

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-5267-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiACDH3_SPHWW
AccessioniPrimary (citable) accession number: A5VGU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: June 24, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.