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A5VGU5 (ACDH3_SPHWW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 3

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3
Gene names
Ordered Locus Names:Swit_4924
Encoded onPlasmid pSWIT02
OrganismSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]
Taxonomic identifier392499 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Acetaldehyde dehydrogenase 3 HAMAP-Rule MF_01657
PRO_0000387744

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2881NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5VGU5 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 53BA565325C87A3E

FASTA31333,107
        10         20         30         40         50         60 
MGKKKVAIIG SGNIGTDLMI KVMRLSEVLE MGVMVGIDPA SDGLARAARM GVATTHKGID 

        70         80         90        100        110        120 
GLLAMPEFAD VEIVFDATSA GAHKRNSELV LAAGKRMIDL TPAAIGPYVI PPVNGDKCLD 

       130        140        150        160        170        180 
ALNVNMVTCG GQATIPIVAA VNRVAKVHYG EIIASIASKS AGPGTRANID EFTETTSQAI 

       190        200        210        220        230        240 
MDVGGATRGK AIIILNPAEP PLIMRDTVYC LCEDADQEAI RQSIHDMVAE VQSYVPGYRL 

       250        260        270        280        290        300 
KQAVQFEHIG SNRPLQIPEM DGEYTGLKVS VFLEVEGAAH YLPSYAGNLD IMTSAAMKTA 

       310 
EKIAARMHEG ATT 

« Hide

References

[1]"Complete sequence of plasmid pSWIT02 of Sphingomonas wittichii RW1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000701 Genomic DNA. Translation: ABQ71544.1.
RefSeqYP_001260311.1. NC_009508.1.

3D structure databases

ProteinModelPortalA5VGU5.
SMRA5VGU5. Positions 3-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392499.Swit_4924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ71544; ABQ71544; Swit_4924.
GeneID5196010.
KEGGswi:Swit_4924.
PATRIC23678647. VBISphWit55028_0300.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMATSAGAHR.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycSWIT392499:GHZK-5267-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH3_SPHWW
AccessionPrimary (citable) accession number: A5VGU5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families