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A5VGU5

- ACDH3_SPHWW

UniProt

A5VGU5 - ACDH3_SPHWW

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Protein
Acetaldehyde dehydrogenase 3
Gene
Swit_4924
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei288 – 2881NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NAD By similarity
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-5267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3
Gene namesi
Ordered Locus Names:Swit_4924
Encoded oniPlasmid pSWIT020 Publication
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Plasmid pSWIT02

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Acetaldehyde dehydrogenase 3UniRule annotation
PRO_0000387744Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_4924.

Structurei

3D structure databases

ProteinModelPortaliA5VGU5.
SMRiA5VGU5. Positions 3-307.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIPEDADH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VGU5-1 [UniParc]FASTAAdd to Basket

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MGKKKVAIIG SGNIGTDLMI KVMRLSEVLE MGVMVGIDPA SDGLARAARM    50
GVATTHKGID GLLAMPEFAD VEIVFDATSA GAHKRNSELV LAAGKRMIDL 100
TPAAIGPYVI PPVNGDKCLD ALNVNMVTCG GQATIPIVAA VNRVAKVHYG 150
EIIASIASKS AGPGTRANID EFTETTSQAI MDVGGATRGK AIIILNPAEP 200
PLIMRDTVYC LCEDADQEAI RQSIHDMVAE VQSYVPGYRL KQAVQFEHIG 250
SNRPLQIPEM DGEYTGLKVS VFLEVEGAAH YLPSYAGNLD IMTSAAMKTA 300
EKIAARMHEG ATT 313
Length:313
Mass (Da):33,107
Last modified:July 10, 2007 - v1
Checksum:i53BA565325C87A3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000701 Genomic DNA. Translation: ABQ71544.1.
RefSeqiYP_001260311.1. NC_009508.1.

Genome annotation databases

EnsemblBacteriaiABQ71544; ABQ71544; Swit_4924.
GeneIDi5196010.
KEGGiswi:Swit_4924.
PATRICi23678647. VBISphWit55028_0300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000701 Genomic DNA. Translation: ABQ71544.1 .
RefSeqi YP_001260311.1. NC_009508.1.

3D structure databases

ProteinModelPortali A5VGU5.
SMRi A5VGU5. Positions 3-307.
ModBasei Search...

Protein-protein interaction databases

STRINGi 392499.Swit_4924.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ71544 ; ABQ71544 ; Swit_4924 .
GeneIDi 5196010.
KEGGi swi:Swit_4924.
PATRICi 23678647. VBISphWit55028_0300.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi IPEDADH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-5267-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiACDH3_SPHWW
AccessioniPrimary (citable) accession number: A5VGU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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