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A5VF70 (A5VF70_SPHWW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Swit_4598
OrganismSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]
Taxonomic identifier392499 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingomonas

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2061Iron By similarity HAMAP MF_00323
Metal binding2841Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A5VF70 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: F2921005C24D767E

FASTA33636,269
        10         20         30         40         50         60 
MSLLPEGHAP VAAPKVGVLI VNLGTPDAPT PGAVRRYLGE FLSDRRVVEI PPIAWQPILR 

        70         80         90        100        110        120 
GIILNVRPRK SAHAYAQVWS EEGSPLAAIT ARQAAALQAR FGGRAIVDHA MRYGKPAIGD 

       130        140        150        160        170        180 
RIAALQAAGC DRILIAPLYP QYCAATTATA NDAAFAVLAK MRWQPAIRTL PPYFDHPAYI 

       190        200        210        220        230        240 
DALAASVRDG LAAFHGEPDA ILASFHGMPA RTLDLGDPYH CHCRKTARLL GDALGRELYV 

       250        260        270        280        290        300 
SFQSRFGRAR WLEPSTEAML DRLAGDGVRR LAVIAPGFSA DCLETLEELA IRGRDRFLAA 

       310        320        330 
GGESFAYLPC LNDGAPGMAM LETLIGDEMK GWIDRP

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References

[1]"Complete sequence of chromosome of Sphingomonas wittichii RW1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000699 Genomic DNA. Translation: ABQ70936.1.
RefSeqYP_001265074.1. NC_009511.1.

3D structure databases

ProteinModelPortalA5VF70.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5VF70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5198051.
GenomeReviewsGene locus Swit_4598 in contig CP000699_GR.
KEGGswi:Swit_4598.
NMPDRfig|392499.4.peg.4613.
PATRIC23688487. VBISphWit55028_5169.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK844073.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5VF70_SPHWW
AccessionPrimary (citable) accession number: A5VF70
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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