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A5VDW3

- A5VDW3_SPHWW

UniProt

A5VDW3 - A5VDW3_SPHWW

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Protein

Alanine racemase

Gene
Swit_4139
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei146 – 1461Substrate By similarityUniRule annotation
Active sitei273 – 2731Proton acceptor; specific for L-alanine By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-4189-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Swit_4139Imported
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_4139.

Structurei

3D structure databases

ProteinModelPortaliA5VDW3.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiQTISHEE.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR000595. cNMP-bd_dom.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VDW3-1 [UniParc]FASTAAdd to Basket

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MNCLEVHRDI GVHEVADRRG NAFQLDERAF HANVEQVRRL LPPGTKIYQC    50
AKGDGYGVGV ERIVCLGVRA GVDGFCLGTP EEALRAKCVA AGRPVLLFAG 100
CDPAALGEMV EAGIIVSISS VEGCEALLRS GATGDVFFKL DCGFRRYGLN 150
EPDLRTVLAR VRRQSSVRCI GAYSHFGSRA DEIVDGGLPL FDRLTRLIED 200
AVQRPIETMV ASSTLILQRP GLGHSAVDPG RLLYGMMAAG PEMPPFQPIV 250
PRISSRLLQV TPFDEARLLT VGYADKTAIP AGGATGVFPL GWIDGLSAHR 300
GFGEVLIRGT RLSVVARTLQ HSIVNLSGLS DVRVGDEVVL VGAQGDEQIG 350
LEAMASAQGM SVTEAHFRLL AAIAAGVPNG RQHG 384
Length:384
Mass (Da):40,870
Last modified:July 10, 2007 - v1
Checksum:i5644A86229A4D5B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ70479.1.
RefSeqiYP_001264617.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ70479; ABQ70479; Swit_4139.
GeneIDi5198492.
KEGGiswi:Swit_4139.
PATRICi23687577. VBISphWit55028_4716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ70479.1 .
RefSeqi YP_001264617.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VDW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_4139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ70479 ; ABQ70479 ; Swit_4139 .
GeneIDi 5198492.
KEGGi swi:Swit_4139.
PATRICi 23687577. VBISphWit55028_4716.

Phylogenomic databases

eggNOGi COG0787.
KOi K01775.
OMAi QTISHEE.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SWIT392499:GHZK-4189-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR000595. cNMP-bd_dom.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiA5VDW3_SPHWW
AccessioniPrimary (citable) accession number: A5VDW3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi