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A5VDW3

- A5VDW3_SPHWW

UniProt

A5VDW3 - A5VDW3_SPHWW

Protein

Alanine racemase

Gene

Swit_4139

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei146 – 1461SubstrateUniRule annotation
    Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-4189-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Swit_4139Imported
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_4139.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VDW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    KOiK01775.
    OMAiQTISHEE.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR000595. cNMP-bd_dom.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VDW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCLEVHRDI GVHEVADRRG NAFQLDERAF HANVEQVRRL LPPGTKIYQC    50
    AKGDGYGVGV ERIVCLGVRA GVDGFCLGTP EEALRAKCVA AGRPVLLFAG 100
    CDPAALGEMV EAGIIVSISS VEGCEALLRS GATGDVFFKL DCGFRRYGLN 150
    EPDLRTVLAR VRRQSSVRCI GAYSHFGSRA DEIVDGGLPL FDRLTRLIED 200
    AVQRPIETMV ASSTLILQRP GLGHSAVDPG RLLYGMMAAG PEMPPFQPIV 250
    PRISSRLLQV TPFDEARLLT VGYADKTAIP AGGATGVFPL GWIDGLSAHR 300
    GFGEVLIRGT RLSVVARTLQ HSIVNLSGLS DVRVGDEVVL VGAQGDEQIG 350
    LEAMASAQGM SVTEAHFRLL AAIAAGVPNG RQHG 384
    Length:384
    Mass (Da):40,870
    Last modified:July 10, 2007 - v1
    Checksum:i5644A86229A4D5B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ70479.1.
    RefSeqiYP_001264617.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ70479; ABQ70479; Swit_4139.
    GeneIDi5198492.
    KEGGiswi:Swit_4139.
    PATRICi23687577. VBISphWit55028_4716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ70479.1 .
    RefSeqi YP_001264617.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5VDW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_4139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ70479 ; ABQ70479 ; Swit_4139 .
    GeneIDi 5198492.
    KEGGi swi:Swit_4139.
    PATRICi 23687577. VBISphWit55028_4716.

    Phylogenomic databases

    eggNOGi COG0787.
    KOi K01775.
    OMAi QTISHEE.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SWIT392499:GHZK-4189-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR000595. cNMP-bd_dom.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273Imported.

    Entry informationi

    Entry nameiA5VDW3_SPHWW
    AccessioniPrimary (citable) accession number: A5VDW3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3