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Protein

Alanine racemase

Gene

Swit_4139

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Swit_4139), Alanine racemase (Swit_0013), Alanine racemase (Swit_0807)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Active sitei273Proton acceptor; specific for L-alanineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-4157-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Swit_4139Imported
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_4139.

Structurei

3D structure databases

ProteinModelPortaliA5VDW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 180Cyclic nucleotide-bindingInterPro annotationAdd BLAST84

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41089U0. Bacteria.
COG0787. LUCA.
KOiK01775.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR000595. cNMP-bd_dom.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VDW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCLEVHRDI GVHEVADRRG NAFQLDERAF HANVEQVRRL LPPGTKIYQC
60 70 80 90 100
AKGDGYGVGV ERIVCLGVRA GVDGFCLGTP EEALRAKCVA AGRPVLLFAG
110 120 130 140 150
CDPAALGEMV EAGIIVSISS VEGCEALLRS GATGDVFFKL DCGFRRYGLN
160 170 180 190 200
EPDLRTVLAR VRRQSSVRCI GAYSHFGSRA DEIVDGGLPL FDRLTRLIED
210 220 230 240 250
AVQRPIETMV ASSTLILQRP GLGHSAVDPG RLLYGMMAAG PEMPPFQPIV
260 270 280 290 300
PRISSRLLQV TPFDEARLLT VGYADKTAIP AGGATGVFPL GWIDGLSAHR
310 320 330 340 350
GFGEVLIRGT RLSVVARTLQ HSIVNLSGLS DVRVGDEVVL VGAQGDEQIG
360 370 380
LEAMASAQGM SVTEAHFRLL AAIAAGVPNG RQHG
Length:384
Mass (Da):40,870
Last modified:July 10, 2007 - v1
Checksum:i5644A86229A4D5B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ70479.1.
RefSeqiWP_012050317.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ70479; ABQ70479; Swit_4139.
KEGGiswi:Swit_4139.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA5VDW3_SPHWW
AccessioniPrimary (citable) accession number: A5VDW3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported