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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Swit_4042
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201701 – 308Methionyl-tRNA formyltransferaseAdd BLAST308

Proteomic databases

PRIDEiA5VDM0

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_4042

Structurei

3D structure databases

ProteinModelPortaliA5VDM0
SMRiA5VDM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A5VDM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAFMGTPD FAVPTLDALV AAGHELAAVY CQPPRPAGRG KALMPSPVQR
60 70 80 90 100
RAEELGIPVR HPVTLRDADA QAVFAALALD VAVVAAYGLI LPQPILDAPR
110 120 130 140 150
HGCLNVHGSL LPRWRGAAPV QRAILAGDPT TGVTIMQMER GLDTGPMLAT
160 170 180 190 200
VETPVDGKTA GELTDELARS GAALMVEVLA DLPAHPPVVQ PEEGVTYAAK
210 220 230 240 250
IDKAESRIDF AEAAGQIERQ VRAFNPAPGA WFEHQGERIR ILACEAVDRH
260 270 280 290 300
GPEAPGAVID DALTIACIDG AIRPTRVQRA GKAAMSAGEL LRGFAIPAGT

QLASPPRT
Length:308
Mass (Da):32,348
Last modified:July 10, 2007 - v1
Checksum:i59C8CA8047441A01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA Translation: ABQ70386.1
RefSeqiWP_012050225.1, NC_009511.1

Genome annotation databases

EnsemblBacteriaiABQ70386; ABQ70386; Swit_4042
KEGGiswi:Swit_4042

Similar proteinsi

Entry informationi

Entry nameiFMT_SPHWW
AccessioniPrimary (citable) accession number: A5VDM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health