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A5VCY9

- PNP_SPHWW

UniProt

A5VCY9 - PNP_SPHWW

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Swit_3810
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851Magnesium By similarity
Metal bindingi491 – 4911Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-3856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Swit_3810
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329859Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_3810.

Structurei

3D structure databases

ProteinModelPortaliA5VCY9.
SMRiA5VCY9. Positions 616-689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61160KH
Add
BLAST
Domaini621 – 68969S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VCY9-1 [UniParc]FASTAAdd to Basket

« Hide

MFDTKKVEIQ WGGQTLTLET GRVARQADGA VLATLGETVV LCAVTAARSV    50
KEGQDFFPLT VHYQEKYFSS GRIPGGFFKR ERGATEKETL VSRLIDRPIR 100
PLFPEGFYNE INVIAQVLSY DGENEPDILA MIAASAALTI SGVPFMGPIG 150
AARVGYKDGE YLLNPTDADV AAGDLDLVVA ATHDAVMMVE SEAKELSEEV 200
MLGAVMFAHK ASQDVIKAII KLAEKSAKDP WEMAPQADLS AAKTKLKKLV 250
GKDITAAYKL TNKSARSSAL NEARAKAKEA FADATPQDQM AAIKLVKKLE 300
AEIVRTAILK DGRRIDGRDT RTVRPIVAEA HFLPRAHGSA LFTRGETQSI 350
STCTLGTKES EQMIDGLNGL RYEHFMLHYN FPPYSVGEVG RFGAPGRREV 400
GHGKLAWRAL HAVLPTKEEF PYTIRLTSDI TESNGSSSMA TVCGGSLAMM 450
DAGVPIKRPV SGIAMGLILE GKDFAVISDI LGDEDHLGDM DFKVAGTSEG 500
ITTMQMDIKI AGITEEIFKT ALLQAKEGRA HILGEMAKAL DHTRTELSAH 550
APRIETMSVP KDKIRDIIGT GGKIIREIVA TTGAKVDIDD DGTVKISSSD 600
TAQIEAARNW IIGIVAEPEV GKIYTGKVVN LVDFGAFVNF MGGKDGLVHV 650
SEIKNERVEK VADALSEGQE VKVKVLEIDN RGKVRLSMRV VDQETGEELP 700
DTRPPREERP RGDRGDRGDR GPRRDGDRRR EGGDRGPRRD RGDRGDRPRR 750
ERSEGGDEGP APDFAPAFLT RDDD 774
Length:774
Mass (Da):84,203
Last modified:July 10, 2007 - v1
Checksum:i3935AAA71652CD47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ70155.1.
RefSeqiWP_012049994.1. NC_009511.1.
YP_001264293.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ70155; ABQ70155; Swit_3810.
GeneIDi5197590.
KEGGiswi:Swit_3810.
PATRICi23686879. VBISphWit55028_4371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ70155.1 .
RefSeqi WP_012049994.1. NC_009511.1.
YP_001264293.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VCY9.
SMRi A5VCY9. Positions 616-689.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_3810.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ70155 ; ABQ70155 ; Swit_3810 .
GeneIDi 5197590.
KEGGi swi:Swit_3810.
PATRICi 23686879. VBISphWit55028_4371.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-3856-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiPNP_SPHWW
AccessioniPrimary (citable) accession number: A5VCY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi