A5VC09 (A5VC09_SPHWW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 2 HAMAP MF_01123
Acyl-activating enzyme 2 HAMAP MF_01123

Gene names

Name:	acsA2 HAMAP MF_01123
Ordered Locus Names:	Swit_3479

Organism

Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]

Taxonomic identifier

392499 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingomonas

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABQ69825.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	514	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A5VC09 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 52E3FE2938F1A8F2	FASTA	645	70,741
	10 20 30 40 50 60 MTDLYPVPAE WAARAKVKDA DYKALYARSI DDAHAFWLEQ AKRLDWVRFP TRTNESSFDE 70 80 90 100 110 120 ADFGVKWFAD GQINVAANCL DRHLAERGDQ VAIIWEPDAP TDAPRRFTYR QVHEEVCRFA 130 140 150 160 170 180 NVLKAQGVKK GDRVTVYLPM IPEAAFALLA CARIGAIHSV VFGGFSPEAL AGRIQDCDSS 190 200 210 220 230 240 IVITADCGRR GGKLVPLKTN VDAAAQHAPS LTSVIVIRAT GAEVPMQAGR DVWYDEAAQG 250 260 270 280 290 300 VSADCPAETM DAEDPLFVLY TSGSTGKPKG VLHTTGGYLL WASLTHELCF DYRPGQIYWC 310 320 330 340 350 360 AADIGWVTGH SYIVYGPLAN GGTTLMYEGV PNWPDASRIW QVVDRHQVEI VFTAPTALRA 370 380 390 400 410 420 LMRDGDEFVA RTSRKSLKLL GTVGEPINPE AWRWYHEVVG EGRCPIVDTW WQTETGAAMI 430 440 450 460 470 480 APLPGATDLK PGSATRPLFG VVPELVDADG QVLEGATDGN LCITRSWPGQ MRTVWGDHAR 490 500 510 520 530 540 FFQTYFSTYK GKYFTGDGCR RDEDGYYWIT GRVDDVINVS GHRMGTAEVE SALVLHAKVA 550 560 570 580 590 600 EAAVVGFPHD IKGQGIYAYV TLNAGEEASE ALRKELRDWV RTEIGPIATP DAIQFAPGLP 610 620 630 640 KTRSGKIMRR ILRKIAEGDV SSLGDTSTLA DPAVVDDLVA NRIKS

References

[1]

"Complete sequence of chromosome of Sphingomonas wittichii RW1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000699 Genomic DNA. Translation: ABQ69825.1.
RefSeq	YP_001263963.1. NC_009511.1.
3D structure databases
ProteinModelPortal	A5VC09.
SMR	A5VC09. Positions 5-642.
ModBase	Search...
Protein-protein interaction databases
STRING	A5VC09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5197757.
GenomeReviews	Gene locus Swit_3479 in contig CP000699_GR.
KEGG	swi:Swit_3479.
NMPDR	fig|392499.4.peg.3598.
PATRIC	23686197. VBISphWit55028_4037.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	LIQWAGG.
ProtClustDB	CLSK857048.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5VC09_SPHWW

Accession

Primary (citable) accession number: A5VC09

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)