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A5VBA0 (TRPC_SPHWW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase

Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:Swit_3219
OrganismSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]
Taxonomic identifier392499 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134
PRO_1000018553

Sequences

Sequence LengthMass (Da)Tools
A5VBA0 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: DC245DBEA71E69B7

FASTA26428,408
        10         20         30         40         50         60 
MSNKLTEICD TKRDHVARRK AETSFAELTA RAKAADAPRG FRAALDRKVA EGGYGLIAEI 

        70         80         90        100        110        120 
KKASPSKGLI RPDFDPPAHA RAYQAAGAAC LSVLTDMPYF QGHDDYLVQA RAACALPALR 

       130        140        150        160        170        180 
KDFIVDPWQV TEARALGADA ILIIVAALDD GQMAEIEAAA IEHGMDALVE VHDADEFDRA 

       190        200        210        220        230        240 
LRLRSRLIGV NNRDLRDFTI DFARTYELVG HAPAGCTFVA ESGLGSKADL DAMADHGVGC 

       250        260 
FLVGESLMRQ DDLAAATRRL LTGA 

« Hide

References

[1]"Complete sequence of chromosome of Sphingomonas wittichii RW1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000699 Genomic DNA. Translation: ABQ69566.1.
RefSeqYP_001263704.1. NC_009511.1.

3D structure databases

ProteinModelPortalA5VBA0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392499.Swit_3219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ69566; ABQ69566; Swit_3219.
GeneID5196199.
KEGGswi:Swit_3219.
PATRIC23685655. VBISphWit55028_3770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230463.
KOK01609.
OMARKDFMFE.
OrthoDBEOG6WT8JX.
ProtClustDBPRK00278.

Enzyme and pathway databases

BioCycSWIT392499:GHZK-3254-MONOMER.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_SPHWW
AccessionPrimary (citable) accession number: A5VBA0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways