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A5VBA0

- TRPC_SPHWW

UniProt

A5VBA0 - TRPC_SPHWW

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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-3254-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:Swit_3219
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Indole-3-glycerol phosphate synthasePRO_1000018553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_3219.

Structurei

3D structure databases

ProteinModelPortaliA5VBA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230463.
KOiK01609.
OMAiRKDFMFE.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VBA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKLTEICD TKRDHVARRK AETSFAELTA RAKAADAPRG FRAALDRKVA
60 70 80 90 100
EGGYGLIAEI KKASPSKGLI RPDFDPPAHA RAYQAAGAAC LSVLTDMPYF
110 120 130 140 150
QGHDDYLVQA RAACALPALR KDFIVDPWQV TEARALGADA ILIIVAALDD
160 170 180 190 200
GQMAEIEAAA IEHGMDALVE VHDADEFDRA LRLRSRLIGV NNRDLRDFTI
210 220 230 240 250
DFARTYELVG HAPAGCTFVA ESGLGSKADL DAMADHGVGC FLVGESLMRQ
260
DDLAAATRRL LTGA
Length:264
Mass (Da):28,408
Last modified:July 10, 2007 - v1
Checksum:iDC245DBEA71E69B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69566.1.
RefSeqiYP_001263704.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69566; ABQ69566; Swit_3219.
GeneIDi5196199.
KEGGiswi:Swit_3219.
PATRICi23685655. VBISphWit55028_3770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69566.1 .
RefSeqi YP_001263704.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VBA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_3219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69566 ; ABQ69566 ; Swit_3219 .
GeneIDi 5196199.
KEGGi swi:Swit_3219.
PATRICi 23685655. VBISphWit55028_3770.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000230463.
KOi K01609.
OMAi RKDFMFE.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00043 .
BioCyci SWIT392499:GHZK-3254-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00134_B. IGPS_B.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiTRPC_SPHWW
AccessioniPrimary (citable) accession number: A5VBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3