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A5VAS1

- A5VAS1_SPHWW

UniProt

A5VAS1 - A5VAS1_SPHWW

Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi196 – 1961Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-3072-MONOMER.
    UniPathwayiUPA00047; UER00057.
    UPA00049; UER00061.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
    Short name:
    DADUniRule annotation
    Gene namesi
    Name:ilvDUniRule annotation
    Ordered Locus Names:Swit_3037Imported
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_3037.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IlvD/Edd family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0129.
    HOGENOMiHOG000173155.
    KOiK01687.
    OMAiRNDARTE.
    OrthoDBiEOG6MSS24.

    Family and domain databases

    HAMAPiMF_00012. IlvD.
    InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view]
    PANTHERiPTHR21000. PTHR21000. 1 hit.
    PfamiPF00920. ILVD_EDD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR00110. ilvD. 1 hit.
    PROSITEiPS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VAS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAYRSRTST HGRNMAGARA LWRATGIKDG DFGKPIIAIA NSFTQFVPGH    50
    IHLKDLGQMV AREIEAHGGI AKEFNTIAVD DGIAQGHLGM LYSLPSREII 100
    ADAVEYMVNA HCADALVCIS NCDKITPGML MAALRLNVPT VFVSGGPMEA 150
    GKIVAADGKL RVIDTVDPMV LAGDPTVSDE EVEAYEKSAC PTCGSCAGMF 200
    TANSMNCLTE ALGLSLPGNG TTLATHADRR SLFLEAARTI MRITRRYYEE 250
    EDGSILPRGI AGFAAFENAM RLDMAMGGST NTILHLLAAA REAEVDFTMA 300
    DIDRLSRDTP CLCKVAPNNS NVHIEDIHRA GGIMSILGQI DRAGLLNRDC 350
    ATIHSPTLAE ALDRWDISRT DDAEVESFYK AAPGGVRTTE AFSQAKRWSE 400
    LDTDRETGVI RSADHAFFKD GGLAVLYGNI ARDGCIVKTA GVDEAILKFS 450
    GSAVICESQD DAVAKILGDK VKAGDVVVVR YEGPKGGPGM QEMLYPTSYL 500
    KARGLGKACA LITDGRFSGA TSGLSIGHVS PEAAEGGAIG LIEDGDIIEI 550
    DIPARRIDVR LSEAELAARR AAMEARGTVA WQPVDRDRPV SMALRAYAAL 600
    TTSAAHGAVR DATQLARR 618
    Length:618
    Mass (Da):65,813
    Last modified:July 10, 2007 - v1
    Checksum:iAB211610947573E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ69387.1.
    RefSeqiYP_001263525.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ69387; ABQ69387; Swit_3037.
    GeneIDi5198274.
    KEGGiswi:Swit_3037.
    PATRICi23685271. VBISphWit55028_3578.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ69387.1 .
    RefSeqi YP_001263525.1. NC_009511.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_3037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ69387 ; ABQ69387 ; Swit_3037 .
    GeneIDi 5198274.
    KEGGi swi:Swit_3037.
    PATRICi 23685271. VBISphWit55028_3578.

    Phylogenomic databases

    eggNOGi COG0129.
    HOGENOMi HOG000173155.
    KOi K01687.
    OMAi RNDARTE.
    OrthoDBi EOG6MSS24.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00057 .
    UPA00049 ; UER00061 .
    BioCyci SWIT392499:GHZK-3072-MONOMER.

    Family and domain databases

    HAMAPi MF_00012. IlvD.
    InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view ]
    PANTHERi PTHR21000. PTHR21000. 1 hit.
    Pfami PF00920. ILVD_EDD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR00110. ilvD. 1 hit.
    PROSITEi PS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273Imported.

    Entry informationi

    Entry nameiA5VAS1_SPHWW
    AccessioniPrimary (citable) accession number: A5VAS1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3