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A5VAS1

- A5VAS1_SPHWW

UniProt

A5VAS1 - A5VAS1_SPHWW

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Protein
Dihydroxy-acid dehydratase
Gene
ilvD, Swit_3037
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotationSAAS annotations

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi196 – 1961Iron-sulfur (4Fe-4S) By similarityUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-3072-MONOMER.
UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:Swit_3037Imported
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_3037.

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0129.
HOGENOMiHOG000173155.
KOiK01687.
OMAiRNDARTE.
OrthoDBiEOG6MSS24.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VAS1-1 [UniParc]FASTAAdd to Basket

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MPAYRSRTST HGRNMAGARA LWRATGIKDG DFGKPIIAIA NSFTQFVPGH    50
IHLKDLGQMV AREIEAHGGI AKEFNTIAVD DGIAQGHLGM LYSLPSREII 100
ADAVEYMVNA HCADALVCIS NCDKITPGML MAALRLNVPT VFVSGGPMEA 150
GKIVAADGKL RVIDTVDPMV LAGDPTVSDE EVEAYEKSAC PTCGSCAGMF 200
TANSMNCLTE ALGLSLPGNG TTLATHADRR SLFLEAARTI MRITRRYYEE 250
EDGSILPRGI AGFAAFENAM RLDMAMGGST NTILHLLAAA REAEVDFTMA 300
DIDRLSRDTP CLCKVAPNNS NVHIEDIHRA GGIMSILGQI DRAGLLNRDC 350
ATIHSPTLAE ALDRWDISRT DDAEVESFYK AAPGGVRTTE AFSQAKRWSE 400
LDTDRETGVI RSADHAFFKD GGLAVLYGNI ARDGCIVKTA GVDEAILKFS 450
GSAVICESQD DAVAKILGDK VKAGDVVVVR YEGPKGGPGM QEMLYPTSYL 500
KARGLGKACA LITDGRFSGA TSGLSIGHVS PEAAEGGAIG LIEDGDIIEI 550
DIPARRIDVR LSEAELAARR AAMEARGTVA WQPVDRDRPV SMALRAYAAL 600
TTSAAHGAVR DATQLARR 618
Length:618
Mass (Da):65,813
Last modified:July 10, 2007 - v1
Checksum:iAB211610947573E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69387.1.
RefSeqiYP_001263525.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69387; ABQ69387; Swit_3037.
GeneIDi5198274.
KEGGiswi:Swit_3037.
PATRICi23685271. VBISphWit55028_3578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69387.1 .
RefSeqi YP_001263525.1. NC_009511.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 392499.Swit_3037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69387 ; ABQ69387 ; Swit_3037 .
GeneIDi 5198274.
KEGGi swi:Swit_3037.
PATRICi 23685271. VBISphWit55028_3578.

Phylogenomic databases

eggNOGi COG0129.
HOGENOMi HOG000173155.
KOi K01687.
OMAi RNDARTE.
OrthoDBi EOG6MSS24.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00057 .
UPA00049 ; UER00061 .
BioCyci SWIT392499:GHZK-3072-MONOMER.

Family and domain databases

HAMAPi MF_00012. IlvD.
InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view ]
PANTHERi PTHR21000. PTHR21000. 1 hit.
Pfami PF00920. ILVD_EDD. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00110. ilvD. 1 hit.
PROSITEi PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiA5VAS1_SPHWW
AccessioniPrimary (citable) accession number: A5VAS1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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