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A5VAS1

- A5VAS1_SPHWW

UniProt

A5VAS1 - A5VAS1_SPHWW

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Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 4Fe-4S cluster.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi196 – 1961Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-3072-MONOMER.
UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:Swit_3037Imported
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_3037.

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0129.
HOGENOMiHOG000173155.
KOiK01687.
OMAiRNDARTE.
OrthoDBiEOG6MSS24.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VAS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAYRSRTST HGRNMAGARA LWRATGIKDG DFGKPIIAIA NSFTQFVPGH
60 70 80 90 100
IHLKDLGQMV AREIEAHGGI AKEFNTIAVD DGIAQGHLGM LYSLPSREII
110 120 130 140 150
ADAVEYMVNA HCADALVCIS NCDKITPGML MAALRLNVPT VFVSGGPMEA
160 170 180 190 200
GKIVAADGKL RVIDTVDPMV LAGDPTVSDE EVEAYEKSAC PTCGSCAGMF
210 220 230 240 250
TANSMNCLTE ALGLSLPGNG TTLATHADRR SLFLEAARTI MRITRRYYEE
260 270 280 290 300
EDGSILPRGI AGFAAFENAM RLDMAMGGST NTILHLLAAA REAEVDFTMA
310 320 330 340 350
DIDRLSRDTP CLCKVAPNNS NVHIEDIHRA GGIMSILGQI DRAGLLNRDC
360 370 380 390 400
ATIHSPTLAE ALDRWDISRT DDAEVESFYK AAPGGVRTTE AFSQAKRWSE
410 420 430 440 450
LDTDRETGVI RSADHAFFKD GGLAVLYGNI ARDGCIVKTA GVDEAILKFS
460 470 480 490 500
GSAVICESQD DAVAKILGDK VKAGDVVVVR YEGPKGGPGM QEMLYPTSYL
510 520 530 540 550
KARGLGKACA LITDGRFSGA TSGLSIGHVS PEAAEGGAIG LIEDGDIIEI
560 570 580 590 600
DIPARRIDVR LSEAELAARR AAMEARGTVA WQPVDRDRPV SMALRAYAAL
610
TTSAAHGAVR DATQLARR
Length:618
Mass (Da):65,813
Last modified:July 10, 2007 - v1
Checksum:iAB211610947573E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ69387.1.
RefSeqiYP_001263525.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69387; ABQ69387; Swit_3037.
GeneIDi5198274.
KEGGiswi:Swit_3037.
PATRICi23685271. VBISphWit55028_3578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ69387.1 .
RefSeqi YP_001263525.1. NC_009511.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_3037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69387 ; ABQ69387 ; Swit_3037 .
GeneIDi 5198274.
KEGGi swi:Swit_3037.
PATRICi 23685271. VBISphWit55028_3578.

Phylogenomic databases

eggNOGi COG0129.
HOGENOMi HOG000173155.
KOi K01687.
OMAi RNDARTE.
OrthoDBi EOG6MSS24.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00057 .
UPA00049 ; UER00061 .
BioCyci SWIT392499:GHZK-3072-MONOMER.

Family and domain databases

HAMAPi MF_00012. IlvD.
InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view ]
PANTHERi PTHR21000. PTHR21000. 1 hit.
Pfami PF00920. ILVD_EDD. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00110. ilvD. 1 hit.
PROSITEi PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273Imported.

Entry informationi

Entry nameiA5VAS1_SPHWW
AccessioniPrimary (citable) accession number: A5VAS1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3