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A5VAK5

- ASSY_SPHWW

UniProt

A5VAK5 - ASSY_SPHWW

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Protein
Argininosuccinate synthase
Gene
argG, Swit_2970
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei95 – 951Citrulline By similarity
Binding sitei120 – 1201ATP; via amide nitrogen By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-3004-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Swit_2970
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Argininosuccinate synthaseUniRule annotation
PRO_0000321318Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi392499.Swit_2970.

Structurei

3D structure databases

ProteinModelPortaliA5VAK5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VAK5-1 [UniParc]FASTAAdd to Basket

« Hide

MSDVKRVVLA FSGGLDTSVI LKWLQQTYQC EVVTFTADLG QGEELEPARA    50
KAKLMGVPDE HIFIDDLREE FVKDYVFPMM RGNALYEGLY LLGTSIARPL 100
IAKRQIEIAR AVGADAVSHG ATGKGNDQVR FELGYYGLAP DIRVIAPWRE 150
WDLTSRTALI DFAEKHQIPV PKDKRGESPF STDANLLHTS SEGKVLEDPW 200
EEVPDYVYSR TVNPEDAPDQ PEIITIDFER GDGVALNGEG MSPATLLTAL 250
NELGRKHGIG RLDLVENRFV GMKSRGMYET PGGAIYHLAH RGIEQITLDR 300
GAAHLKDELA PRYAELIYNG FWFSPEREML QAAIDHSQEK VTGTVRLKLY 350
KGGVHVIGRK SPYTLYSEKV VTFEDDAGAY DQRDAAGFIK LNALRLRLLG 400
RRDGR 405
Length:405
Mass (Da):45,236
Last modified:July 10, 2007 - v1
Checksum:i5AFEDB4309D9896D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69321.1.
RefSeqiWP_012049171.1. NC_009511.1.
YP_001263459.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69321; ABQ69321; Swit_2970.
GeneIDi5200714.
KEGGiswi:Swit_2970.
PATRICi23685129. VBISphWit55028_3508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69321.1 .
RefSeqi WP_012049171.1. NC_009511.1.
YP_001263459.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VAK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69321 ; ABQ69321 ; Swit_2970 .
GeneIDi 5200714.
KEGGi swi:Swit_2970.
PATRICi 23685129. VBISphWit55028_3508.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SWIT392499:GHZK-3004-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiASSY_SPHWW
AccessioniPrimary (citable) accession number: A5VAK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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