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A5VA89

- SYL_SPHWW

UniProt

A5VA89 - SYL_SPHWW

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Protein

Leucine--tRNA ligase

Gene
leuS, Swit_2852
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei615 – 6151ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Swit_2852
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Leucine--tRNA ligaseUniRule annotationPRO_0000334823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2852.

Structurei

3D structure databases

ProteinModelPortaliA5VA89.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi612 – 6165"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VA89-1 [UniParc]FASTAAdd to Basket

« Hide

MSARFNHLKA DAHWQGVWES QGTFQARDDS PKPKSYVLEM FPYPSGRIHM    50
GHVRNYTMGD VLARYRRMKG FEVLHPMGWD AFGMPAENAA MEKKVHPGDW 100
TRANIAAMRD QLKRIGFALD WSRELATCEP DYYGQEQALF LDLYAAGLVY 150
RKESAVNWDP VDMTVLANEQ VIDGRGWRSG ALVERRKLNQ WFLKITDFAD 200
DLLDGLDTLD QWPEKVRTMQ ENWIGKSQGM RFTFVLDAPA GDLTSFDVFT 250
TRPDTMFGAS FAAIAADHPI AQALSAGNPA LQAFIADCKR TGTAAAEIET 300
AEKKGYDTGL SVVHPLDPDW KLPLFVANFV LMDYGTGAVF GCPAHDQRDL 350
DFARKYALPV KRVVAPSPEE AAAPIGDEAY VGPGRIVNSA FLDGLSVEEA 400
KAAVIARAEA GGWGQGTTVW RLRDWGVSRQ RYWGTPIPII HCEGCGAVPV 450
PHDQLPVVLP EDVAFDIPGN PLDRHPTWKH VDCPSCGKPA RRETDTLDTF 500
VDSSWYFIRF ASQPSDKPFD RAVAESWMPV GQYIGGVEHA ILHLLYARFW 550
TRALERIGRI GVKEPFTGLF TQGMVTHETY KDPAGQWLSP EEVSDGIVVA 600
TGAPATVGRI EKMSKSKKNV VDPAPIVEQY GADAVRWFML SDSPPERDLE 650
WTESGIEGCW RFVNRLWRIT DVSEAGDGED RELDRKLHKA IAGIAADIEA 700
LGFNRAVAKI HELSNAIEKA APSASRAAAA RALVRLVAPM VPHLAEEAWA 750
RLGEQGLVAD AAWPAHDPAL LVDDEVTIAV QVNGKLRDTL TAPKGAPKDA 800
LERMALESEK ITRLLEGAAP RKVIVVPDRL VNIVA 835
Length:835
Mass (Da):92,289
Last modified:July 10, 2007 - v1
Checksum:iD328A1D3BF136638
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69205.1.
RefSeqiWP_012049055.1. NC_009511.1.
YP_001263343.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69205; ABQ69205; Swit_2852.
GeneIDi5197900.
KEGGiswi:Swit_2852.
PATRICi23684879. VBISphWit55028_3383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69205.1 .
RefSeqi WP_012049055.1. NC_009511.1.
YP_001263343.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VA89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69205 ; ABQ69205 ; Swit_2852 .
GeneIDi 5197900.
KEGGi swi:Swit_2852.
PATRICi 23684879. VBISphWit55028_3383.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-2886-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiSYL_SPHWW
AccessioniPrimary (citable) accession number: A5VA89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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