Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5VA89

- SYL_SPHWW

UniProt

A5VA89 - SYL_SPHWW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei615 – 6151ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-2886-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Swit_2852
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_0000334823Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_2852.

    Structurei

    3D structure databases

    ProteinModelPortaliA5VA89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi612 – 6165"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5VA89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSARFNHLKA DAHWQGVWES QGTFQARDDS PKPKSYVLEM FPYPSGRIHM    50
    GHVRNYTMGD VLARYRRMKG FEVLHPMGWD AFGMPAENAA MEKKVHPGDW 100
    TRANIAAMRD QLKRIGFALD WSRELATCEP DYYGQEQALF LDLYAAGLVY 150
    RKESAVNWDP VDMTVLANEQ VIDGRGWRSG ALVERRKLNQ WFLKITDFAD 200
    DLLDGLDTLD QWPEKVRTMQ ENWIGKSQGM RFTFVLDAPA GDLTSFDVFT 250
    TRPDTMFGAS FAAIAADHPI AQALSAGNPA LQAFIADCKR TGTAAAEIET 300
    AEKKGYDTGL SVVHPLDPDW KLPLFVANFV LMDYGTGAVF GCPAHDQRDL 350
    DFARKYALPV KRVVAPSPEE AAAPIGDEAY VGPGRIVNSA FLDGLSVEEA 400
    KAAVIARAEA GGWGQGTTVW RLRDWGVSRQ RYWGTPIPII HCEGCGAVPV 450
    PHDQLPVVLP EDVAFDIPGN PLDRHPTWKH VDCPSCGKPA RRETDTLDTF 500
    VDSSWYFIRF ASQPSDKPFD RAVAESWMPV GQYIGGVEHA ILHLLYARFW 550
    TRALERIGRI GVKEPFTGLF TQGMVTHETY KDPAGQWLSP EEVSDGIVVA 600
    TGAPATVGRI EKMSKSKKNV VDPAPIVEQY GADAVRWFML SDSPPERDLE 650
    WTESGIEGCW RFVNRLWRIT DVSEAGDGED RELDRKLHKA IAGIAADIEA 700
    LGFNRAVAKI HELSNAIEKA APSASRAAAA RALVRLVAPM VPHLAEEAWA 750
    RLGEQGLVAD AAWPAHDPAL LVDDEVTIAV QVNGKLRDTL TAPKGAPKDA 800
    LERMALESEK ITRLLEGAAP RKVIVVPDRL VNIVA 835
    Length:835
    Mass (Da):92,289
    Last modified:July 10, 2007 - v1
    Checksum:iD328A1D3BF136638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ69205.1.
    RefSeqiWP_012049055.1. NC_009511.1.
    YP_001263343.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ69205; ABQ69205; Swit_2852.
    GeneIDi5197900.
    KEGGiswi:Swit_2852.
    PATRICi23684879. VBISphWit55028_3383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ69205.1 .
    RefSeqi WP_012049055.1. NC_009511.1.
    YP_001263343.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5VA89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_2852.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ69205 ; ABQ69205 ; Swit_2852 .
    GeneIDi 5197900.
    KEGGi swi:Swit_2852.
    PATRICi 23684879. VBISphWit55028_3383.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SWIT392499:GHZK-2886-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273.

    Entry informationi

    Entry nameiSYL_SPHWW
    AccessioniPrimary (citable) accession number: A5VA89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3