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Protein

NAD(P)H dehydrogenase (quinone)

Gene

Swit_2810

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121NAD(P)UniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei134 – 1341FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 145FMNUniRule annotation
Nucleotide bindingi110 – 16253FMNUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:Swit_2810
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199NAD(P)H dehydrogenase (quinone)PRO_1000084148Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2810.

Structurei

3D structure databases

ProteinModelPortaliA5VA47.
SMRiA5VA47. Positions 3-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 190187Flavodoxin-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiQAGGLWM.
OrthoDBiEOG6384K0.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5VA47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKILVLYYS TYGHIETMAE AIAEGARSAG AEVDVKRVPE TVPLDIAEKN
60 70 80 90 100
HFKLDQKAPV ATVAELEDYD AIIVGTGTRF GRMSSQMAAF LDGAGGLWAR
110 120 130 140 150
GALNGKVGAA FASTATQHGG QETTLFSIIT NLLHFGMTIV GLPYAYQGQM
160 170 180 190
GVDEVKGGAP YGATTIADGD GSRQPSATDL DGARFQGRHV AEITAKLVG
Length:199
Mass (Da):20,863
Last modified:July 10, 2007 - v1
Checksum:iB6B794C62ABB8F8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ69163.1.
RefSeqiWP_012049013.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69163; ABQ69163; Swit_2810.
KEGGiswi:Swit_2810.
PATRICi23684791. VBISphWit55028_3339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ69163.1.
RefSeqiWP_012049013.1. NC_009511.1.

3D structure databases

ProteinModelPortaliA5VA47.
SMRiA5VA47. Positions 3-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi392499.Swit_2810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ69163; ABQ69163; Swit_2810.
KEGGiswi:Swit_2810.
PATRICi23684791. VBISphWit55028_3339.

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiQAGGLWM.
OrthoDBiEOG6384K0.

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2844-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiNQOR_SPHWW
AccessioniPrimary (citable) accession number: A5VA47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: January 20, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.