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A5VA34

- GLSA_SPHWW

UniProt

A5VA34 - GLSA_SPHWW

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Protein
Glutaminase
Gene
glsA, Swit_2796
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei172 – 1721Substrate By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei248 – 2481Substrate By similarity
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:Swit_2796
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318GlutaminaseUniRule annotation
PRO_0000336041Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi392499.Swit_2796.

Structurei

3D structure databases

ProteinModelPortaliA5VA34.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5VA34-1 [UniParc]FASTAAdd to Basket

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MPVTVAPDLQ AIVDRIAAEM AGREERGKVA DYIPGLARVD PKHFGIAVAT    50
HDGRMFAAGD ADMAFSIQSV SKVFALTIAL GKVGDALWKR VGREPSGNAF 100
NSIVQLEAEQ GIPRNPFINA GAIVVSDVVL AGHAPKEAIG EILRFVRDLA 150
GDDGIVVDDE VAQGEADTGF RNAALANYMR SFGNILHPVD QVLGVYFHQC 200
ALAMSCRQLA RAGRFLMHEG QHPDTGFNIV SPMRARRINA LMMLCGHYDG 250
SGEFAFRVGI PGKSGVGGGI LCVVPGIASI AVWSPGLNER GNSTLGSLAL 300
ERLAAATGWS VFNQREPG 318
Length:318
Mass (Da):33,703
Last modified:July 10, 2007 - v1
Checksum:i1AD368F661EC78C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69150.1.
RefSeqiYP_001263288.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69150; ABQ69150; Swit_2796.
GeneIDi5196866.
KEGGiswi:Swit_2796.
PATRICi23684763. VBISphWit55028_3325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69150.1 .
RefSeqi YP_001263288.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5VA34.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69150 ; ABQ69150 ; Swit_2796 .
GeneIDi 5196866.
KEGGi swi:Swit_2796.
PATRICi 23684763. VBISphWit55028_3325.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-2830-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiGLSA_SPHWW
AccessioniPrimary (citable) accession number: A5VA34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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