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A5V9T6

- GCSPA_SPHWW

UniProt

A5V9T6 - GCSPA_SPHWW

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, Swit_2696
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Swit_2696
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000045678Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi392499.Swit_2696.

Structurei

3D structure databases

ProteinModelPortaliA5V9T6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A5V9T6-1 [UniParc]FASTAAdd to Basket

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MRYLPLTDAD RSAMLARIGA ASIDDLFVDV PEAARLAGPI AGLPAHASEL    50
AVERHMSRLA RRNLSAGEAP FFLGCGAYRH HVPASVDHLI QRGEFLTSYT 100
PYQPEIAQGT LQALFEFQTQ VARLFGCDVA NASMYDGSTA CWEAITMARR 150
VTKRDKAILS AGLHPHYVSL AKTMARFTGD RLDAAIPDLT PGAPGDDMAR 200
LLAAIDGETS CVVVQNPNIL GHVADLSELA ARCHEKGALL VAVVTEPVAL 250
GAIRSPGEMG ADIVVGEGQS IGVGLNFGGP YVGLFACAEK HVRQMPGRLA 300
GVTADADGQR GFVLTLSTRE QHIRREKATS NICTNAGLCA LAFSVHLTLL 350
GETGLRRLAE LNHAGAVAAA ERLAQVPGVE LVNGAFFNEF TLKLPREARP 400
VVRSLADKGI LGGVSLGRLY PGEAALAGGL VVAVTETASA EDVETLAQAL 450
EAEIAA 456
Length:456
Mass (Da):47,981
Last modified:July 10, 2007 - v1
Checksum:i2FC5AD05EA83E46C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69052.1.
RefSeqiYP_001263190.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ69052; ABQ69052; Swit_2696.
GeneIDi5199862.
KEGGiswi:Swit_2696.
PATRICi23684555. VBISphWit55028_3221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ69052.1 .
RefSeqi YP_001263190.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5V9T6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ69052 ; ABQ69052 ; Swit_2696 .
GeneIDi 5199862.
KEGGi swi:Swit_2696.
PATRICi 23684555. VBISphWit55028_3221.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-2730-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiGCSPA_SPHWW
AccessioniPrimary (citable) accession number: A5V9T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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