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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Swit_2696
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456781 – 456Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST456

Proteomic databases

PRIDEiA5V9T6

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi392499.Swit_2696

Structurei

3D structure databases

ProteinModelPortaliA5V9T6
SMRiA5V9T6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A5V9T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTDAD RSAMLARIGA ASIDDLFVDV PEAARLAGPI AGLPAHASEL
60 70 80 90 100
AVERHMSRLA RRNLSAGEAP FFLGCGAYRH HVPASVDHLI QRGEFLTSYT
110 120 130 140 150
PYQPEIAQGT LQALFEFQTQ VARLFGCDVA NASMYDGSTA CWEAITMARR
160 170 180 190 200
VTKRDKAILS AGLHPHYVSL AKTMARFTGD RLDAAIPDLT PGAPGDDMAR
210 220 230 240 250
LLAAIDGETS CVVVQNPNIL GHVADLSELA ARCHEKGALL VAVVTEPVAL
260 270 280 290 300
GAIRSPGEMG ADIVVGEGQS IGVGLNFGGP YVGLFACAEK HVRQMPGRLA
310 320 330 340 350
GVTADADGQR GFVLTLSTRE QHIRREKATS NICTNAGLCA LAFSVHLTLL
360 370 380 390 400
GETGLRRLAE LNHAGAVAAA ERLAQVPGVE LVNGAFFNEF TLKLPREARP
410 420 430 440 450
VVRSLADKGI LGGVSLGRLY PGEAALAGGL VVAVTETASA EDVETLAQAL

EAEIAA
Length:456
Mass (Da):47,981
Last modified:July 10, 2007 - v1
Checksum:i2FC5AD05EA83E46C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA Translation: ABQ69052.1
RefSeqiWP_012048904.1, NC_009511.1

Genome annotation databases

EnsemblBacteriaiABQ69052; ABQ69052; Swit_2696
KEGGiswi:Swit_2696

Entry informationi

Entry nameiGCSPA_SPHWW
AccessioniPrimary (citable) accession number: A5V9T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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